S-{[(4-氯苯基)硫代]甲基}-O,O-二乙基硫代磷酸酯 | 7173-84-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: S-{[(4-氯苯基)硫代]甲基}-O,O-二乙基硫代磷酸酯
• 英文名称: S-(4-chlorophenylthio)methyl diethyl phosphorothiolate
• 英文别名: O,o-diethyl-S-p-chlorophenylthiomethyl-thiophosphate；Monothiophosphorsaeure-O,O-diaethyl-S-<4-chlor-phenylmercaptomethyl>-ester；Monothiophosphorsaeure-O,O-diaethyl-S-(4-chlor-phenylmercaptomethyl)-ester；Danifos；1-chloro-4-(diethoxyphosphorylsulfanylmethylsulfanyl)benzene
• CAS: 7173-84-4
• 化学式: C₁₁H₁₆ClO₃PS₂
• 分子量: 326.805
• InChiKey: ZSAZGCBSZUURAX-UHFFFAOYSA-N

物化性质

• 保留指数：
  2207.6;2198.1

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  86.1
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 危险等级：
  6.1(a)
• 危险品运输编号：
  UN 3018
• 包装等级：
  II
• 危险类别：
  6.1(a)

反应信息

• 作为反应物：
  描述：

  S-{[(4-氯苯基)硫代]甲基}-O,O-二乙基硫代磷酸酯 在 四(三苯基膦)钯 作用下， 生成 十二硫醇
  参考文献：
  名称：

  Method of preparing photochromic article

  摘要：

  一种制备交联聚合物制品的方法，包括：提供可交联的聚合物浇铸组合物；和光致变色组合物；将可交联的聚合物浇铸组合物部分固化，使聚合物达到或超过其凝胶点；将部分固化的胶状聚合物与光致变色组合物接触；并固化胶状聚合物。

  公开号：

  US05882556A1
• 作为产物：
  描述：

  4-chloro-benzenesulfenyl chloride 以 乙醚 、 氯仿 为溶剂， 反应 6.0h， 生成 S-{[(4-氯苯基)硫代]甲基}-O,O-二乙基硫代磷酸酯
  参考文献：
  名称：

  Miyamoto, Toru; Yamamoto, Izuru, Agricultural and Biological Chemistry, 1980, vol. 44, # 11, p. 2581 - 2586

  摘要：

  DOI：

文献信息

• TOPICAL GEL FORMULATION COMPRISING ORGANOPHOSPHATE INSECTICIDE AND PREPARATION THEREOF
  申请人：Goyal Sandhya

  公开号：US20120053153A1

  公开（公告）日：2012-03-01

  The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

  本发明提供了一种适用于治疗哺乳动物体内寄生虫的局部凝胶制剂，包括：a）约0.1-10％的杀虫剂重量；b）至少约75％的有机溶剂，所述有机溶剂选自较低的烷基醇，酮，乙二醇和其混合物组成的群体，其中所述有机溶剂含有至少约40％的较低的烷基醇重量；c）至少一种聚合物，所述聚合物选自纤维素聚合物，丙烯酸酯，甲基丙烯酸酯和聚乙烯吡咯烷酮组成的群体。本凝胶制剂首选含有马拉硫磷，可选择含异丙酸肉豆蔻酸酯。本发明还提供了一种制备方法以及使用该制剂治疗哺乳动物体内寄生虫的方法。
• Topical gel formulation comprising organophosphate insecticide and its preparation thereof
  申请人：Goyal Sandhya

  公开号：US20060084632A1

  公开（公告）日：2006-04-20

  The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

  本发明提供了一种适用于治疗哺乳动物体外寄生虫的杀虫剂局部凝胶药物制剂，包括： a) 约 0.1-10% (重量)的杀虫剂；b) 至少约 75% (重量)的有机溶剂，该有机溶剂选自由低级烷基醇、酮、乙二醇及其混合物组成的组，其中有机溶剂含有至少约 40% (重量)的低级烷基醇；和 c) 至少一种聚合物，该聚合物选自由纤维素聚合物、丙烯酸酯、甲基丙烯酸酯和聚乙烯吡咯烷酮组成的组。本发明的凝胶药物制剂最好含有马拉硫磷，并可选择含有肉豆蔻酸异丙酯。本发明进一步提供了一种制备方法以及使用本发明治疗哺乳动物体外寄生虫的方法。
• MIYAMOTO TORU; YAMAMOTO IZURU, AGR. AND BIOL. CHEM., 1980, 44, NO 11, 2581-2586
  作者：MIYAMOTO TORU、 YAMAMOTO IZURU

  DOI：——

  日期：——
• ORGANOPHOSPHOROUS COMPOSITIONS
  申请人：BASF CORPORATION

  公开号：EP1315421B1

  公开（公告）日：2004-06-02
• Topical gel formulation comprising insecticide and its preparation thereof
  申请人：Goyal Sandhya

  公开号：US20060121073A1

  公开（公告）日：2006-06-08

  The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

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