disodium;4-(2-dodecoxyethoxy)-4-oxo-2-sulfonatobutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: disodium;4-(2-dodecoxyethoxy)-4-oxo-2-sulfonatobutanoate
• 化学式: C18H32Na2O8S
• 分子量: 454.5
• InChiKey: ZZTKVOKJMCZYBC-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.47
• 重原子数：
  29
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  141
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Film-forming compositions and methods
  申请人：3M Innovative Properties Company

  公开号：EP1849487A2

  公开（公告）日：2007-10-31

  Film-forming compositions, as well as methods of making and using, wherein the compositions include an optional active agent, water, a surfactant, and a water-soluble or water-dispersible vinyl polymer comprising amine group-containing side-chains and a copolymerized hydrophobic monomer; wherein the amine equivalent weight of the polymer is at least about 300 grams polymer per equivalent of amine group.

  成膜组合物以及制造和使用方法，其中组合物包括任选活性剂、水、表面活性剂以及水溶性或水分散性乙烯基聚合物，该聚合物包含含胺基的侧链和共聚疏水单体；其中聚合物的胺基当量重量至少为每当量胺基约 300 克聚合物。
• Antiseptic compositions and methods
  申请人：3M Innovative Properties Company

  公开号：EP1955594A1

  公开（公告）日：2008-08-13

  The present invention relates to an antiseptic composition comprising an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least about 0.25 wt-%; a hydroxycarboxylic acid buffer in an amount in excess of 5 wt-%; and water.

  本发明涉及一种防腐组合物，该组合物包含一种选自由 I2、碘伏及其组合组成的组的抗菌剂，其中抗菌剂的用量足以提供至少约 0.25 wt-% 的可用碘浓度；一种用量超过 5 wt-% 的羟基羧酸缓冲剂；以及水。
• IMPROVED METHOD FOR REMOVING BACTERIAL BIOFILMS AND TREATING TISSUE
  申请人：Infection Elimination Services LLC

  公开号：EP3498261A1

  公开（公告）日：2019-06-19

  A treatment mixture for treating biofilms on a human or animal is provided. The treatment mixture comprises: an effective amount of a salt of alkyleth sulfate defined by Formula I:          R1-(OCHR2CH2)n-OSO3X1     Formula I wherein: R1 is a branched or unbranched alkyl of 8-24 carbons; R2 is hydrogen or methyl; n is an integer of 2 to 30; and each X1 is independently a counter ion; an effective amount of at least one surfactant selected from the group consisting of a salt of alkyl sulfoacetate defined by Formula II:          R4OC(O)CH2SO3X2     Formula II wherein R4 is a branched or unbranched alkyl of 8-24 carbons; and X2 is a counter ion; and an effective amount of a salt of an alkyl sulfosuccinate defined by Formula III: wherein: R3 is the branched or unbranched alkyl group of an alkyl alcohol with the alcohol hydrogen replaced with the sulfosuccinate wherein the alkyl has of 8-24 carbons, more preferably 10-18 carbons and most preferably 12-14 carbons; and X is a counter ion; and an effective amount of a zinc salt.

  提供了一种用于治疗人或动物身上生物膜的治疗混合物。该治疗混合物包括 有效量的由式 I 定义的烷基硫酸盐： R1-(OCHR2CH2)n-OSO3X1 式 I 其中 R1 是碳原子数为 8-24 的支链或未支链烷基； R2 是氢或甲基 n 是 2 至 30 的整数；以及 每个 X1 都是独立的反离子； 有效量的至少一种表面活性剂，该表面活性剂选自由式 II 定义的磺基乙酸烷基酯盐组成的组： R4OC(O)CH2SO3X2 式 II 其中 R4 是 8-24 碳的支链或未支链烷基；和 X2 是反离子； 和有效量的由式 III 定义的烷基磺基琥珀酸盐： 其中 R3 是烷基醇的支链或未支链烷基，醇氢被磺基琥珀酸酯取代，其中烷基具有 8-24 个碳原子，更优选 10-18 个碳原子，最优选 12-14 个碳原子；以及 X 是反离子；以及 有效量的锌盐。
• Method for removing bacterial biofilms
  申请人：Infection Elimination Services, LLC

  公开号：US10206899B2

  公开（公告）日：2019-02-19

  A treatment mixture for treating biofilms on a human or animal is provided. The treatment mixture comprises: an effective amount of a salt of alkyleth sulfate defined by Formula I: R1—(OCHR2CH2)n—OSO3X1  Formula I wherein: R1 is a branched or unbranched alkyl of 8-24 carbons; R2 is hydrogen or methyl; n is an integer of 2 to 30; and each X1 is independently a counter ion; an effective amount of at least one surfactant selected from the group consisting of a salt of alkyl sulfoacetate defined by Formula II: R4OC(O)CH2SO3X2  Formula II wherein R4 is a branched or unbranched alkyl of 8-24 carbons; and X2 is a counter ion; and an effective amount of a salt of an alkyl sulfosuccinate defined by Formula III: wherein: R3 is the branched or unbranched alkyl group of an alkyl alcohol with the alcohol hydrogen replaced with the sulfosuccinate wherein the alkyl has of 8-24 carbons, more preferably 10-18 carbons and most preferably 12-14 carbons; and X is a counter ion.

  提供了一种用于治疗人或动物身上生物膜的治疗混合物。治疗混合物包括 有效量的由式 I 定义的烷基硫酸盐： R1-(OCHR2CH2)n-OSO3X1 式 I 其中 R1 是碳原子数为 8-24 的支链或未支链烷基； R2 是氢或甲基 n 是 2 至 30 的整数；以及 每个 X1 都是独立的反离子； 有效量的至少一种表面活性剂，该表面活性剂选自由式 II 定义的磺基乙酸烷基酯盐组成的组： R4OC(O)CH2SO3X2 式 II 其中 R4 是 8-24 碳的支链或未支链烷基；和 X2 是反离子； 和有效量的由式 III 定义的烷基磺基琥珀酸盐： 其中 R3 是烷基醇的支链或未支链烷基，醇氢被磺基琥珀酸酯取代，其中烷基的碳原子数为 8-24 个，更优选为 10-18 个，最优选为 12-14 个；以及 X 是反离子。
• Composition for improving function of aortic endothelial cell and use thereof
  申请人：XI'AN JIAOTONG UNIVERSITY

  公开号：US10576049B1

  公开（公告）日：2020-03-03

  The disclosure relates to a composition for improving aortic endothelial cell function and use thereof. The composition includes acetic acid, lactic acid, polyoxyethylene castor oil, and disodium alkyl polyoxyethylene sulfosuccinate. The composition is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by saturated fatty acids, increasing a mitochondrial respiration and metabolism of vascular endothelial cells, and preventing an occurrence and progression of atherosclerosis. The composition is capable of reducing human aortic endothelial inflammation caused by saturated fatty acids, for example, reducing the mRNA levels of interleukin-6 (IL-6) and matrix metalloproteinase-1 (MMP-1), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by saturated fatty acids, for example, increasing the expression of mitochondrial complexes I and III and mitochondrial metabolism-associated Foxo1.

  本公开涉及一种用于改善主动脉内皮细胞功能的组合物及其用途。该组合物包括醋酸、乳酸、聚氧乙烯蓖麻油和烷基聚氧乙烯醚磺基琥珀酸二钠。该组合物能够抑制饱和脂肪酸引起的人体主动脉内皮细胞的炎症反应，提高血管内皮细胞的线粒体呼吸和新陈代谢，防止动脉粥样硬化的发生和发展。该组合物能够减轻饱和脂肪酸引起的人体主动脉内皮炎症，例如降低白细胞介素-6（IL-6）和基质金属蛋白酶-1（MMP-1）的 mRNA 水平，并能有效保护人体主动脉内皮细胞中线粒体的功能不受饱和脂肪酸的损害，例如增加线粒体复合物 I 和 III 以及线粒体代谢相关 Foxo1 的表达。