H-Ala-OH.H-Tyr-OH.H-Glu-OH | 31325-29-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Ala-OH.H-Tyr-OH.H-Glu-OH
• 英文别名: (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2-aminopentanedioic acid;(2S)-2-aminopropanoic acid
• CAS: 31325-29-8
• 化学式: C17H27N3O9
• 分子量: 417.4
• InChiKey: ZZUBXZOYYZOVLC-QIKNFSLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.97
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  248
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• Adsorbent of beta 2-microglobulin
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0319144A1

  公开（公告）日：1989-06-07

  An adsorbent for β2-microglobulin is disclosed, which comprises a water-insoluble carrier having supported thereon, as a ligand, at least one electrolyte selected from the group consisting of a polyamino acid, a polysaccharide, a synthetic high polymer, collagen having an isoelectric point of 9.5 or more, and gelatin having an isoelectric point of 6.5 or more, wherein said electrolyte has a molecular weight not less than 1,000 and an X value of more than 2.0, wherein X is a relationship regarding the skeleton structure of said electrolyte and is the sum of A and B, wherein A represents (the number of carbon atoms of the skeleton structure) - (the number of hydrophilic groups /(the number of hydrophilic groups); and B represents |(the number of cationic groups) - (the number of anionic groups)l/(the number of hydrophilic groups). The adsorbent exhibits adsorptivity for β2- microglobulin at high efficiency and high selectivity.

  本发明公开了一种用于吸附β2-微球蛋白的吸附剂，它包括一种水不溶性载体，其上作为配体支撑着至少一种电解质，该电解质选自由聚氨基酸、多糖、合成高聚物、等电点大于或等于 9.5 的胶原蛋白和等电点大于或等于 6.5 的明胶组成的组，其中所述电解质的分子量不小于 1 000，X 值大于 2.0，其中X是关于所述电解质的骨架结构的关系，是A和B的总和，其中A代表(骨架结构的碳原子数)-(亲水基团数/(亲水基团数))；B代表|(阳离子基团数)-(阴离子基团数)l/(亲水基团数)。该吸附剂对 β2- 微球蛋白具有高效率和高选择性的吸附能力。
• PROCESS FOR THE PREPARATION OF RANDOM POLYPEPTIDES AND EMPLOYING CIRCULAR DICHROISM AS A GUIDANCE TOOL FOR THE MANUFACTURE OF GLATIRAMER ACETATE
  申请人：Biocon Limited

  公开号：EP2773652A1

  公开（公告）日：2014-09-10
• US5051185A
  申请人：——

  公开号：US5051185A

  公开（公告）日：1991-09-24
• [EN] PROCESS FOR THE PREPARATION OF RANDOM POLYPEPTIDES AND EMPLOYING CIRCULAR DICHROISM AS A GUIDANCE TOOL FOR THE MANUFACTURE OF GLATIRAMER ACETATE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE POLYPEPTIDES ALÉATOIRES ET UTILISATION DU DICHROÏSME CIRCULAIRE À TITRE D'OUTIL DE GUIDAGE POUR LA PRODUCTION D'ACÉTATE DE GLATIRAMÈRE
  申请人：BIOCON LTD

  公开号：WO2013065071A1

  公开（公告）日：2013-05-10

  The present invention discloses novel process for the preparation of mixture of polypeptides comprising L-Glutamaic acid, L-Alanine, L-Tyrosine, and L-Lysine.by employing circular dichroism as a guidance tool.