毒理性
哺乳期间使用总结：本记录中的信息指的是作为诊断剂使用的锝Tc 99m二巯基丁酸（Tc 99m DMSA）。美国核能管理委员会的一个小组委员会建议，为了简化指导建议，在给予所有锝Tc 99m诊断产品后，应该停止哺乳24小时，尽管这个时间间隔可能比必要的要长。其他专家表示，在给予锝Tc 99m DMSA后，不需要中断哺乳。然而，为了遵循将暴露“尽可能合理地降至最低”的原则，一些专家建议在给予放射性药物前哺乳婴儿，并在给药后中断哺乳3到6小时，然后完全挤出一次乳汁并丢弃。如果母亲在检查前已经挤出并保存了乳汁，她可以在哺乳中断期间喂给婴儿。母亲在通常的临床剂量后不需要避免与婴儿近距离接触。
担心乳汁中放射性水平的母亲可以要求在医院核医学科进行检测。当放射性水平达到安全水平时，她可以恢复哺乳。已经发布了一种测量乳汁放射性和确定母亲可以安全恢复哺乳时间的方法。
对于在工作场所接触Tc 99m物质的哺乳母亲，除了适当的普通辐射防护措施外，不需要采取任何预防措施。
◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。
◉ 对哺乳和乳汁的影响：截至修订日期，没有找到相关的已发布信息。
◉ Summary of Use during Lactation:Information in this record refers to the use of technetium Tc 99m dimercaptosuccinic acid (Tc 99m DMSA) as a diagnostic agent. A US Nuclear Regulatory Commission subcommittee has recommended that nursing be discontinued for 24 hours after administration of all technetium Tc 99m diagnostic products to simplify guidance recommendations, although this time interval may be longer than necessary. Other experts state that breastfeeding need not be interrupted after administration of technetium Tc 99m DMSA. However, to follow the principle of keeping exposure "as low as reasonably achievable", some experts recommend nursing the infant just before administration of the radiopharmaceutical and interrupting breastfeeding for 3 to 6 hours after the dose, then expressing the milk completely once and discarding it. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption. Mothers need not refrain from close contact with their infants after usual clinical doses.
Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level, she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.
For nursing mothers who work with Tc 99m substances in their workplace, there is no need to take any precautions other than those appropriate for general radiation protection.
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
