2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid;2-((2S,6R)-6-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl)acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid;2-((2S,6R)-6-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl)acetic acid
• 英文别名: 2-[(2S)-6-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
• 化学式: C₂₃H₂₈N₂O₅S₂
• 分子量: 476.6
• InChiKey: FIQOFIRCTOWDOW-DXCJPMOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Method for preventing lung diseases in smokers and non-smokers using antihypertensive drug
  申请人：SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION

  公开号：US11123335B2

  公开（公告）日：2021-09-21

  The present invention relates to a method for inhibiting lung diseases in smokers and non-smokers by blocking growth factor signaling using an antihypertensive drug, and more particularly, to a pharmaceutical composition for preventing lung cancer or emphysema, which contains an antihypertensive drug as an active ingredient. The present invention suggests a novel use of an antihypertensive drug which is being used in clinics, to prevent lung diseases, and therefore, may be readily applied to early lung cancer or a lung cancer high-risk group, and particularly may exclude safety concerns accompanying clinical application of novel drugs, thereby increasing clinical applicability. In addition, enormous costs and time needed from development to clinical use of new drugs may be dramatically reduced.

  本发明涉及一种通过使用抗高血压药物阻断生长因子信号转导来抑制吸烟者和非吸烟者肺部疾病的方法，更具体地说，涉及一种用于预防肺癌或肺气肿的药物组合物，该组合物含有抗高血压药物作为活性成分。本发明提出了一种抗高血压药物的新用途，这种药物目前已在临床上用于预防肺部疾病，因此，可以很容易地应用于早期肺癌或肺癌高危人群，特别是可以排除新型药物临床应用中的安全问题，从而提高临床适用性。此外，新药从研发到临床应用所需的巨额成本和时间也可能大大减少。
• Nanoparticulate stabilized anti-hypertensive compositions
  申请人：Jenkins Scott

  公开号：US20100028439A1

  公开（公告）日：2010-02-04

  The present invention is directed to anti-hypertensive compositions comprising a nanoparticulate temocapril, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate temocapril particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of hypertension and related diseases.
• METHODS FOR BREAST CANCER SCREENING AND TREATMENT
  申请人：White David

  公开号：US20100029734A1

  公开（公告）日：2010-02-04

  A method for selecting a breast cancer patient for therapy with an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor, comprises (a) determining whether the cancer comprises a tumor that is estrogen receptor positive (ER+) and (b) selecting the patient for such therapy only if the cancer is determined to comprise an ER+ tumor. A method for treating breast cancer in a patient further comprises (c) administering to the patient, if so selected, an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor. A method for treating a breast tumor in a patient having SERM-resistant ER+ breast cancer comprises administering to the patient an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor. A therapeutic combination useful in treatment of a breast tumor comprises an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor, and a second agent that comprises (a) an aromatase inhibitor or (b) an estrogen receptor modulator or antagonist.
• NANOPARTICULATE STABILIZED ANTI-HYPERTENSIVE COMPOSITIONS
  申请人：Jenkins Scott

  公开号：US20120076863A1

  公开（公告）日：2012-03-29

  The present invention is directed to anti-hypertensive compositions comprising a nanoparticulate temocapril, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate temocapril particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of hypertension and related diseases.
• METHOD FOR PREVENTING LUNG DISEASES IN SMOKERS AND NON-SMOKERS USING ANTIHYPERTENSIVE DRUG
  申请人：SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION

  公开号：US20180125833A1

  公开（公告）日：2018-05-10

  The present invention relates to a method for inhibiting lung diseases in smokers and non-smokers by blocking growth factor signaling using an antihypertensive drug, and more particularly, to a pharmaceutical composition for preventing lung cancer or emphysema, which contains an antihypertensive drug as an active ingredient. The present invention suggests a novel use of an antihypertensive drug which is being used in clinics, to prevent lung diseases, and therefore, may be readily applied to early lung cancer or a lung cancer high-risk group, and particularly may exclude safety concerns accompanying clinical application of novel drugs, thereby increasing clinical applicability. In addition, enormous costs and time needed from development to clinical use of new drugs may be dramatically reduced.