Acetamide, N-(1-methylethyl)-N-2-propenyl- | 3829-78-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetamide, N-(1-methylethyl)-N-2-propenyl-
• 英文别名: N-propan-2-yl-N-prop-2-enylacetamide
• CAS: 3829-78-5
• 化学式: C₈H₁₅NO
• 分子量: 141.21
• InChiKey: WWRGSYIINZQXLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
  申请人：——

  公开号：US20020045759A1

  公开（公告）日：2002-04-18

  The present invention is directed to peptidomimetic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

  本发明涉及抑制异戊二烯蛋白转移酶和癌基因蛋白Ras的预尾基类似物化合物。该发明进一步涉及含有本发明化合物的化疗组合物以及用于抑制异戊二烯蛋白转移酶和癌基因蛋白Ras的预尾基化的方法。
• Inhibitors of prenyl-protein transferase
  申请人：——

  公开号：US20020010184A1

  公开（公告）日：2002-01-24

  The present invention comprises piperazinone-containing compounds which inhibit prenyl-protein transferases, including famesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.

  该发明涉及含有哌嗪酮类化合物，可抑制前列蛋白转移酶，包括法美基蛋白转移酶和戈楞基蛋白转移酶I型。这种治疗性化合物对癌症的治疗具有用处。
• Detection of biomolecules by sensitizer-linked substrates
  申请人：Gray B. Harry

  公开号：US20070112180A1

  公开（公告）日：2007-05-17

  Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic applications of the inventions are also included.

  本发明揭示了利用敏化剂-连接底物分子检测和表征目标生物分子的方法和组合物。还包括高通量筛选测定和治疗应用的发明。
• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE LA PRENYL-PROTEINE TRANSFERASE
  申请人：MERCK & CO INC

  公开号：WO2001017992A1

  公开（公告）日：2001-03-15

  The present invention is directed to compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

  本发明涉及抑制异戊二烯基-蛋白转移酶及癌基因蛋白Ras的异戊二烯基化的化合物。本发明还涉及包含本发明化合物的化疗组合物以及抑制异戊二烯基-蛋白转移酶及癌基因蛋白Ras的异戊二烯基化的方法。
• Alpha-Ketoglutarates and Their Use as Therapeutic Agents
  申请人：Gottlieb Eyal

  公开号：US20090005437A1

  公开（公告）日：2009-01-01

  The present invention relates generally to the field of pharmaceuticals and medicine. More particularly, the present invention relates to certain compounds (e.g., α-ketoglutarate compounds; compounds that activate HIFα hydroxylase; compounds that increases the level of α-ketoglutarate, etc.) and their use in medicine, for example, in the treatment of cancer (e.g., cancer in which the activity of one of the enzymes in the tricarboxylic acid (TCA) cycle is down regulated), in the treatment of angiogenesis (e.g., hypoxia-induced angiogenesis). One preferred class of compounds are α-ketoglutarate compounds having a hydrophobic moiety that is, or is part of, an ester group formed from one of the acid groups of α-ketogluartic acid; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, N-oxides, chemically protected forms, and prodrugs thereof.

  本发明一般涉及制药和医学领域。更具体地说，本发明涉及某些化合物（例如α-酮戊二酸化合物；激活HIFα羟化酶的化合物；增加α-酮戊二酸水平的化合物等）及其在医学上的应用，例如治疗癌症（例如三羧酸循环中的酶活性被下调的癌症），治疗血管生成（例如缺氧诱导的血管生成）。一种首选的化合物类别是具有亲水性基团的α-酮戊二酸化合物，该亲水性基团是α-酮戊二酸的酸基之一形成的酯基或其一部分；以及其药学上可接受的盐、溶剂化物、酰胺、酯、醚、N-氧化物、化学保护形式和其前药。