S-甲基-甲基对硫磷 | 597-89-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: S-甲基-甲基对硫磷
• 英文名称: (+/-)-isoparathion methyl
• 英文别名: O,S-dimethyl O'-(4-nitrophenyl) thiophosphate；O,S-Dimethyl-O-<4-nitro-phenyl>-thiophosphat；O,S-Dimethyl-<4-nitro-phenyl>-phosphorothioat；Thiophosphorsaeure-O,S-dimethylester-O'-<4-nitro-phenylester>；(+/-)-thiophosphoric acid O,S-dimethyl ester-O'-(4-nitro-phenyl ester)；(+/-)-Thiophosphorsaeure-O,S-dimethylester-O'-(4-nitro-phenylester)；O,S-Dimethyl O-(p-nitrophenyl) phosphorothioate；1-[methoxy(methylsulfanyl)phosphoryl]oxy-4-nitrobenzene
• CAS: 597-89-7
• 化学式: C₈H₁₀NO₅PS
• 分子量: 263.211
• InChiKey: IVNMMKOOGWCFRS-UHFFFAOYSA-N

物化性质

• 熔点：
  43 °C(Solv: methanol (67-56-1))
• 沸点：
  371.1±44.0 °C(Predicted)
• 密度：
  1.413±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  S-甲基-甲基对硫磷 在 劳森试剂 作用下， 以 甲苯 为溶剂， 以80%的产率得到O,S-dimethyl O-p-nitrophenyl phosphorodithioate
  参考文献：
  名称：

  Biocatalytic oxidation of thiophosphoryl compounds: a new chemo-enzymatic approach to enantiomeric insecticidal thionophosphates and their oxons

  摘要：

  The biocatalytic oxidation of racemic O-S-dimethyl O-p-nitrophenyl phosphorodithioate 5 catalyzed by chloroperoxidase from Caldariomyces fumago resulted in the formation of the (-)-(S)-enantiomer of the corresponding oxon 4 and unoxidized substrate 5 with a (+)-(R)-configuration. Both compounds were obtained with very high enantiomeric excesses, 99.6% and 97%, respectively. The thionation reaction of the resulting (-)-(S)-oxon 4 with Lawesson's reagent gave (-)-(S)-phosphorodithioate 5 with full stereoselectivity, while the oxidation of unreacted substrate (+)-(R)-5 with iodoxybenzene afforded oxon (+)-(R)-4 with 94.9% ee. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.031
• 作为产物：
  描述：

  (+-)-thiophosphoric acid O-methyl ester-O'-(4-nitro-phenyl ester); tetramethylammonium salt 在 氯化苄 作用下， 生成 S-甲基-甲基对硫磷
  参考文献：
  名称：

  Thuong,N.T. et al., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1970, vol. 270, p. 89 - 91

  摘要：

  DOI：
• 作为试剂：
  描述：

  (+-)-thiophosphoric acid O-methyl ester-O'-(4-nitro-phenyl ester); tetramethylammonium salt 在 S-甲基-甲基对硫磷 作用下， 生成 thiophosphoric acid S-methyl ester-O-(4-nitro-phenyl ester); tetramethylammonium salt
  参考文献：
  名称：

  Hilgetag,G.; Lehmann,G., Journal fur praktische Chemie (Leipzig 1954), 1960, vol. 12, p. 6 - 10

  摘要：

  DOI：

文献信息

• Granular controlled release agrochemical compositions and process for the preparation thereof
  申请人：Everris International B.V.

  公开号：EP2545775A2

  公开（公告）日：2013-01-16

  A granular agrochemical composition is disclosed including a granular core material having a water soluble portion with a first coating layer applied on the surface of the core material and a second coating layer applied on the surface of the first coating layer. The first coating layer includes a wax composition having a biologically active ingredient incorporated therein and the second coating layer includes a polymeric composition.; The granular agrochemical composition exhibits a controlled rate of release of the biologically active ingredient therefrom over a period greater than about 30 days from the date of initial exposure of the granular composition to moisture whereby essentially all of the biologically active ingredient incorporated in the wax material of the first coating layer is released from the granular composition before the water soluble portion of the granular core material is released from the granular composition.

  本发明公开了一种颗粒状农用化学品组合物，包括一种颗粒状芯材，芯材具有水溶性部分，芯材表面涂有第一涂布层，第一涂布层表面涂有第二涂布层。颗粒状农用化学品组合物显示出生物活性成分从颗粒状组合物中释放的可控速率，从颗粒状组合物最初暴露于湿气之日起超过约 30 天的时间内，颗粒状组合物中的生物活性成分基本上全部从第一涂布层的蜡材料中释放出来，然后颗粒状芯材的水溶性部分才从颗粒状组合物中释放出来。
• Hilgetag et al., Journal fur praktische Chemie (Leipzig 1954), 1959, vol. <4> 8, p. 207,215
  作者：Hilgetag et al.

  DOI：——

  日期：——
• METHOD OF TREATING AND DIAGNOSING SLEEP DISORDERED BREATHING AND MEANS FOR CARRYING OUT THE METHOD
  申请人：A+ Science Invest AB

  公开号：EP0923370A2

  公开（公告）日：1999-06-23
• ACETYL CHOLINE ESTERASE INHIBITORS FOR TREATING AND DIAGNOSING SLEEP DISORDERED BREATHING
  申请人：Curapath AB

  公开号：EP0923370B1

  公开（公告）日：2005-11-16
• GRANULAR CONTROLLED RELEASE AGROCHEMICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Everris International B.V.

  公开号：EP1928231B1

  公开（公告）日：2014-03-12