(NZ)-N-[1-(1,3-benzodioxol-5-yl)ethylidene]hydroxylamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (NZ)-N-[1-(1,3-benzodioxol-5-yl)ethylidene]hydroxylamine
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: BDSUJNDSNUKNAU-POHAHGRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  51
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (NZ)-N-[1-(1,3-benzodioxol-5-yl)ethylidene]hydroxylamine 在 盐酸 、 sodium hydroxide 、 铁粉 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 0.5h， 生成 N-[[4-[[(Z)-1-(1,3-benzodioxol-5-yl)ethylideneamino]oxymethyl]phenyl]carbamoyl]-2,6-difluorobenzamide
  参考文献：
  名称：

  Synthesis and bioassay evaluation of 1-(4-substitutedideneaminooxymethyl)-phenyl-3-(2,6-difluorobenzoyl)ureas

  摘要：

  A variety of novel 1-(4-substitutedideneaminooxymethyl)-phenyl-3-(2,6-difluorobenzoyl)ureas were designed and synthesized by the reaction of 4-substitutedideneaminooxyrnethyl aniline with 2,6-difluorobenzoyl isocyanates in good yields. The title compounds were soluble in most organic solvents, which should make them easier to use. The preliminary bioassay showed that some of the title compounds show excellent insecticidal activity against Mythimna separata at the dosage of 25 mg kg(-1) and moderate insecticidal activity against Nephotettix cincticeps at the dosage of 500 mg kg(-1). Toxicity assays indicated that these title compounds cause in M. separata and N. cincticeps such symptoms of toxicity as discolouration, and weight loss, and cessation of feeding and lethal. One title compound exhibited acaricidal activity against Tetranychus urticae. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.03.049

文献信息

• CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF
  申请人：Gin David

  公开号：US20110071097A1

  公开（公告）日：2011-03-24

  The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of using said compounds or compositions in the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease. The invention further provides methods of using said compounds or compositions in the treatment of multidrug resistant cancer.

  本发明提供了新型的头孢松酯、其合成方法以及中间体。本发明还提供了包括本发明化合物的药物组合物，以及使用该化合物或组合物治疗增生性疾病（例如良性肿瘤、癌症、炎症性疾病、自身免疫疾病、糖尿病性视网膜病变）和传染病的方法。本发明还提供了使用该化合物或组合物治疗多药耐药癌症的方法。
• BAX INHIBITORS AND USES THEREOF
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  公开号：US20220389028A1

  公开（公告）日：2022-12-08

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• US8466142B2
  申请人：——

  公开号：US8466142B2

  公开（公告）日：2013-06-18
• US9006231B2
  申请人：——

  公开号：US9006231B2

  公开（公告）日：2015-04-14
• [EN] BAX INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE BAX ET LEURS UTILISATIONS
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2021002986A2

  公开（公告）日：2021-01-07

  A compound having formula (I) or (II) for use inhibiting Bax mediated cell death and/or apoptosis.