2-tert-butyl-2-(2-chlorobenzoyl)-N-phenylhydrazinecarboxamide | 403739-84-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-tert-butyl-2-(2-chlorobenzoyl)-N-phenylhydrazinecarboxamide
• 英文别名: 1-[tert-butyl-(2-chlorobenzoyl)amino]-3-phenylurea
• CAS: 403739-84-4
• 化学式: C₁₈H₂₀ClN₃O₂
• 分子量: 345.829
• InChiKey: REYAQKZXZNMOAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  草酰氯 、 2-tert-butyl-2-(2-chlorobenzoyl)-N-phenylhydrazinecarboxamide 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 生成 N-tert-Butyl-2-chloro-N-(2,4,5-trioxo-3-phenyl-imidazolidin-1-yl)-benzamide
  参考文献：
  名称：

  Synthesis and biological activity of novel N ′- tert -butyl- N ′-substituted benzoyl- N -(substituted phenyl)aminocarbonylhydrazines and their derivatives

  摘要：

  Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N'-tert-butyl-N'-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01932-3
• 作为产物：
  描述：

  N'-tert-Butyl-N'-(2-chloro-benzoyl)-hydrazinecarboxylic acid benzyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 生成 2-tert-butyl-2-(2-chlorobenzoyl)-N-phenylhydrazinecarboxamide
  参考文献：
  名称：

  Synthesis and biological activity of novel N ′- tert -butyl- N ′-substituted benzoyl- N -(substituted phenyl)aminocarbonylhydrazines and their derivatives

  摘要：

  Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N'-tert-butyl-N'-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01932-3

文献信息

• Synthesis and biological activity of novel N ′- tert -butyl- N ′-substituted benzoyl- N -(substituted phenyl)aminocarbonylhydrazines and their derivatives
  作者：Qingmin Wang、Runqiu Huang

  DOI：10.1016/s0040-4039(01)01932-3

  日期：2001.12

  Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N'-tert-butyl-N'-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities. (C) 2001 Elsevier Science Ltd. All rights reserved.