(3S)-4-azaniumyl-3-phenylbutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-4-azaniumyl-3-phenylbutanoate
• 化学式: C10H13NO2
• 分子量: 179.22
• InChiKey: DAFOCGYVTAOKAJ-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  [(3R)-4,4-dimethyl-2-oxooxolan-3-yl] (3S)-4-(1,3-dioxoisoindol-2-yl)-3-phenylbutanoate 生成 (3S)-4-azaniumyl-3-phenylbutanoate
  参考文献：
  名称：

  ALLAN, R. D.;BATES, M. C.;DREW, C. A.;DUKE, R. K.;HAMBREY, T. W.;JOHNSTON+, TETRAHEDRON, 46,(1990) N, C. 2511-2524

  摘要：

  DOI：

文献信息

• Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid
  申请人：Yasuoka Junichi

  公开号：US20090137819A1

  公开（公告）日：2009-05-28

  The present invention provides a method of producing a compound (IIa) or a compound (IIb), provides a method of producing a compound (IIIa) or a compound (IIIb), provides a method of producing a compound (Va) or its salt or a compound (Vb) or its salt, provides a method of producing a compound (IIIa) or a compound (IIIb), further, provides a method of producing a compound (Va) or its salt or a compound (Vb) or its salt including these production methods.

  本发明提供了生产化合物（IIa）或化合物（IIb）的方法，提供了生产化合物（IIIa）或化合物（IIIb）的方法，提供了生产化合物（Va）或其盐或化合物（Vb）或其盐的方法，提供了生产化合物（IIIa）或化合物（IIIb）的方法，此外，还提供了生产化合物（Va）或其盐或化合物（Vb）或其盐的方法，包括这些生产方法。
• METHOD OF PRODUCING PURIFIED OPTICALLY ACITVE 4-AMINO-3-(SUBSTITUTED PHENYL)BUTANOIC ACID COMPOUND
  申请人：Murakami Kazuo

  公开号：US20110087049A1

  公开（公告）日：2011-04-14

  A method of producing a purified optically active 4-amino-3-(substituted phenyl)butanoic acid compound which is characterized by comprising a step of making a crude optically active 4-amino-3-(substituted phenyl)butanoic acid compound contact an organic acid in the presence of water.

  一种制备纯化的光学活性4-氨基-3-(取代苯基)丁酸化合物的方法，其特征在于包括在水的存在下，使粗光学活性4-氨基-3-(取代苯基)丁酸化合物与有机酸接触的步骤。
• Bifunctional chiral organocatalytic compound having excellent enantioselectivity, preparation method therefor, and method for producing non-natural gamma-amino acid from nitro compound by using same
  申请人：KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

  公开号：US11465135B2

  公开（公告）日：2022-10-11

  The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using the chiral organocatalytic compound. According to the present invention, the bifunctional chiral organocatalytic compound having excellent enantioselectivity can be easily synthesized, gamma-amino acids with high optical selectivity can be obtained at a high yield by an economical and convenient method using the chiral organocatalytic compound, and various (R)-configuration gamma-amino acids, which are not present in nature, can be produced with high optical purity in large quantities by using a small amount of a catalyst, and therefore, the present invention can be widely utilized in various industrial fields including the pharmaceutical industry.

  本发明涉及一种具有优异对映选择性的双功能手性有机催化化合物、其制备方法以及利用该手性有机催化化合物从硝基化合物制备非天然γ-氨基酸的方法。根据本发明，可以很容易地合成具有优异对映选择性的双功能手性有机催化化合物，并通过使用该手性有机催化化合物的经济、简便的方法高产率地获得具有高光学选择性的γ-氨基酸、而且只需使用少量催化剂，就能大量生产出自然界中不存在的各种(R)构型γ-氨基酸，且光学纯度高，因此本发明可广泛应用于包括制药业在内的各种工业领域。
• ALLAN, R. D.;BATES, M. C.;DREW, C. A.;DUKE, R. K.;HAMBREY, T. W.;JOHNSTON+, TETRAHEDRON, 46,(1990) N, C. 2511-2524
  作者：ALLAN, R. D.、BATES, M. C.、DREW, C. A.、DUKE, R. K.、HAMBREY, T. W.、JOHNSTON+

  DOI：——

  日期：——
• ALLAN, R. D.;BATES, M. C.;DREW, C. A.;DUKE, R. K.;HAMBLEY, T. W.;JOHNSTON+, TETRAHEDRON, 46,(1990) N, C. 2511-2524
  作者：ALLAN, R. D.、BATES, M. C.、DREW, C. A.、DUKE, R. K.、HAMBLEY, T. W.、JOHNSTON+

  DOI：——

  日期：——