(5E)-5-[(5-phenylfuran-2-yl)methylidene]-2-sulfanylideneimidazolidin-4-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (5E)-5-[(5-phenylfuran-2-yl)methylidene]-2-sulfanylideneimidazolidin-4-one
• 化学式: C₁₄H₁₀N₂O₂S
• 分子量: 270.31
• InChiKey: DCDOWOKNRNAXRO-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages
  申请人：Michelet Jean-Francois

  公开号：US20060034786A1

  公开（公告）日：2006-02-16

  Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

  15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，例如四唑、苯基吡唑、苯基呋喃、苯基噻吩、苯基吡唑、吡唑羧酰胺、2-硫代乙酰胺和偶氮化合物，可用于促进或刺激皮肤和/或皮肤附属物的色素沉淀和/或预防和/或限制皮肤和/或皮肤附属物的脱色和/或变白，特别是用于预防和/或限制白发。
• Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses
  申请人：Boulle Christophe

  公开号：US20060008436A1

  公开（公告）日：2006-01-12

  Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or salt thereof: in which Hy is a heterocycle of 4 to 7 atoms, optionally comprising carbonyl/thiocarbonyl functional groups, and G is O, S or NH.

  杂环化合物对于刺激/诱导角质纤维生长，特别是人类头发/睫毛的生长和/或减缓它们的脱落很有用，其结构式(I)或其盐如下：其中Hy是由4至7个原子组成的杂环，可选包括羰基/硫代羰基官能团，而G是O，S或NH。
• INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES
  申请人：MICHELET JEAN-FRANCOIS

  公开号：US20110014250A1

  公开（公告）日：2011-01-20

  Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

  15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，例如四唑、苯乙烯吡唑、苯并呋喃、苯并硫吩、苯并吡唑、吡唑羧酰胺、2-硫代乙酰胺和偶氮化合物，可用于促进或刺激皮肤和/或皮肤附属物的色素沉着，或预防和/或限制皮肤和/或皮肤附属物的脱色和/或变白，特别是预防和/或限制白发。
• Utilisation d'un inhibiteur de 15-hydroxy prostaglandine déshydrogénase pour favoriser la pigmentation de la peau ou des phanères
  申请人：L'Oréal

  公开号：EP1594438B1

  公开（公告）日：2013-07-17
• Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses
  申请人：Boulle Christophe

  公开号：US20080076809A1

  公开（公告）日：2008-03-27

  The invention relates to a composition for caring for or making up keratinous fibers comprising a heterocyclic compound of formula (I) or of one of its salts: in which: Hy is a heterocycle of 4 to 7 atoms comprising a carbonyl functional group and/or a thiocarbonyl functional group and optionally being substituted and G, R 1 , R 2 and R 3 are defined in the description.