Disodium;3-[(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)imino]-3-oxido-2-thiophen-3-ylpropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Disodium;3-[(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)imino]-3-oxido-2-thiophen-3-ylpropanoate
• 英文别名: disodium;3-[(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)imino]-3-oxido-2-thiophen-3-ylpropanoate
• 化学式: C15H14N2Na2O6S2
• 分子量: 428.4
• InChiKey: ZBBCUBMBMZNEME-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -8.11
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  183
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Potassium channel mediated delivery of agents through the blood-brain barrier
  申请人：Black L. Keith

  公开号：US20050089473A1

  公开（公告）日：2005-04-28

  This invention includes pharmaceutical compositions, methods and kits for the treatment or diagnosis of a malignant tumors, including brain tumors, and diseases or disorders characterized by abnormal brain tissue.

  本发明包括用于治疗或诊断恶性肿瘤（包括脑肿瘤）以及以脑组织异常为特征的疾病或紊乱的药物组合物、方法和试剂盒。
• METHOD FOR TREATING SKIN DISORDERS WITH XANTHOPHYLLS
  申请人：Leonard Todd

  公开号：US20060122282A1

  公开（公告）日：2006-06-08

  The present invention provides for a method for treating a skin disorder in a mammal inflicted with a skin disorder. The present invention also provides for a method for retarding or reversing the loss of collagen fibers, abnormal changes in elastic fibers, or deterioration of small blood vessels in sundamaged mammalian skin. The present invention also provides for a method for exfoliating the skin surface of a mammal. The present invention also provides for a method for treating or preventing acne or a pimple in a mammal in need thereof. The methods include topically administering, to a mammal in need of such treatment, a composition that includes xanthophylls in a nontoxic amount, effective to treat the skin disorder.

  本发明提供了一种治疗患有皮肤病的哺乳动物的皮肤病的方法。本发明还提供了一种方法，用于延缓或逆转受损哺乳动物皮肤中胶原纤维的流失、弹性纤维的异常变化或小血管的恶化。本发明还提供了一种去除哺乳动物皮肤表面角质的方法。本发明还提供了一种治疗或预防哺乳动物痤疮或粉刺的方法。该方法包括向需要治疗的哺乳动物局部施用一种组合物，该组合物包括无毒量的黄绿素，可有效治疗皮肤疾病。
• POTASSIUM CHANNEL MEDIATED DELIVERY OF AGENTS THROUGH THE BLOOD-BRAIN BARRIER
  申请人：Cedars-Sinai Medical Center

  公开号：EP1663239A2

  公开（公告）日：2006-06-07
• EP1663239A4
  申请人：——

  公开号：EP1663239A4

  公开（公告）日：2008-07-23
• Compositions useful to treat ocular neovascular diseases and macular degeneration
  申请人：Leonard Todd

  公开号：US20060134226A1

  公开（公告）日：2006-06-22

  The present invention provides a composition that includes: (a) xanthophylls; (b) vitamin C; (c) vitamin E; (d) zinc; and (e) copper. The present invention also provides a method of treating macular degeneration in a human, inhibiting angiogenesis in a human, preventing impairment of the vision or for improving impaired vision of a human whose eye has drusen, and/or treating a disease associated with ocular neovascularitis in a human. The methods include administering to a human in need of such treatment an effective amount of the composition of the present invention.