N,N,N-trimethyl-2-phenoxyethanaminium | 6779-86-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N,N,N-trimethyl-2-phenoxyethanaminium
• 英文别名: trimethyl(2-phenoxyethyl)azanium
• CAS: 6779-86-8
• 化学式: C11H18NO+
• 分子量: 180.27
• InChiKey: VCXBSHBJVUIQHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] NOVEL ROCK INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE ROCK
  申请人：AMAKEM NV

  公开号：WO2014068035A1

  公开（公告）日：2014-05-08

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases. Compounds of the invention display soft drug characteristics, i.e. they are rapidly inactivated upon entry in the systemic circulation. Therefore, they allow for reduced systemic exposure to functionally active ROCK inhibitors.

  本发明涉及新型激酶抑制剂，更具体地说是ROCK抑制剂，包括含有此类抑制剂的组合物，尤其是药物，以及此类抑制剂在治疗和预防疾病中的用途。特别是，本发明涉及新型ROCK抑制剂，包括含有此类抑制剂的组合物，尤其是药物，以及此类抑制剂在治疗和预防疾病中的用途。此外，本发明还涉及治疗方法和使用所述化合物在制造药剂中的应用，用于治疗包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病等多种治疗适应症。本发明的化合物表现出软药特性，即它们在进入系统循环后迅速失活。因此，它们允许减少对功能活性ROCK抑制剂的系统性暴露。
• [EN] NOVEL SOFT PDE4 INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DOUX DE PDE4
  申请人：AMAKEM NV

  公开号：WO2013021021A1

  公开（公告）日：2013-02-14

  The present invention relates to new phosphodiesterase inhibitors, more specifically soft PDE4 inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new soft PDE4 inhibitors compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including inflammatory diseases.

  本发明涉及新的磷酸二酯酶抑制剂，更具体地说是软PDE4抑制剂，包括这些抑制剂的组合物，特别是制药品，以及这些抑制剂在疾病的治疗和预防中的用途。具体来说，本发明涉及新的软PDE4抑制剂组合物，特别是包括这些抑制剂的制药品，以及这些抑制剂在疾病的治疗和预防中的用途。此外，本发明涉及治疗方法和使用上述化合物制造药物的方法，适用于多种治疗适应症，包括炎症性疾病。
• NOVEL SOFT PDE4 INHIBITORS
  申请人：Leysen Dirk

  公开号：US20140187555A1

  公开（公告）日：2014-07-03

  The present invention relates to new phosphodiesterase inhibitors, more specifically soft PDE4 inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new soft PDE4 inhibitors compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including inflammatory diseases.

  本发明涉及新的磷酸二酯酶抑制剂，更具体地是软性PDE4抑制剂，包括这种抑制剂的组合物，特别是制药用途的组合物，并且涉及使用这种抑制剂来治疗和预防疾病的用途。特别地，本发明涉及新的软性PDE4抑制剂组合物，特别是制药用途的组合物，并且涉及使用这种抑制剂来治疗和预防疾病的用途。此外，本发明还涉及治疗方法和使用所述化合物制造药物，用于多种治疗适应症，包括炎症性疾病。
• [EN] BIPHENYLCARBOXAMIDES AS ROCK KINASE INHIBITORS<br/>[FR] BIPHÉNYLCARBOXAMIDES UTILISÉS EN TANT QU'INHIBITEURS DE KINASE ROCK
  申请人：AMAKEM NV

  公开号：WO2013030367A1

  公开（公告）日：2013-03-07

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases, gastrointestinal diseases and respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地说是ROCK抑制剂，以及包含这些抑制剂的组合物，特别是药物组合物，并且涉及这些抑制剂在治疗和预防疾病方面的用途。特别地，本发明涉及新的ROCK抑制剂，包括这些抑制剂的组合物，特别是药物组合物，并且涉及这些抑制剂在治疗和预防疾病方面的用途。此外，本发明还涉及治疗和使用上述化合物制造药物的方法，适用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病、胃肠疾病和呼吸系统疾病。
• [EN] NOVEL SOFT ROCK INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS ROCK ASSOUPLISSANTS
  申请人：AMAKEM NV

  公开号：WO2013030366A1

  公开（公告）日：2013-03-07

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases and ophthalmic diseases.

  本发明涉及新的激酶抑制剂，更具体地说是ROCK抑制剂，包括此类抑制剂的组合物，特别是制药用组合物，以及在治疗和预防疾病中使用此类抑制剂的用途。特别是，本发明涉及新的ROCK抑制剂，包括此类抑制剂的组合物，特别是制药用组合物，以及在治疗和预防疾病中使用此类抑制剂的用途。此外，本发明还涉及治疗方法和使用所述化合物制造药物的方法，用于多种治疗适应症，包括性功能障碍、炎症性疾病和眼科疾病。