Dibutylazanium;phosphono hydrogen phosphate | 59562-58-2

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: Dibutylazanium;phosphono hydrogen phosphate
• 英文别名: dibutylazanium;phosphono hydrogen phosphate
• CAS: 59562-58-2
• 化学式: C8H23NO7P2
• 分子量: 307.22
• InChiKey: GFFBAXKJVPVOAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  136
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• 4 -THIONUCLEOTIDE
  申请人：Geneticlab Co., Ltd.

  公开号：EP1541581A1

  公开（公告）日：2005-06-15

  Disclosed is a compound of formula I: [wherein B is a nucleobase selected from the group consisting of adenine, guanine, cytosine, uracil and hypoxanthine], a compound of formula II: [wherein B' is a nucleobase selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and hypoxanthine], a method for synthesizing these nucleoside triphosphates, and a process for producing an oligonucleotide using these nucleoside triphosphates.

  公开了一种式子为I的化合物：[其中B是从腺嘌呤，鸟嘌呤，胞嘧啶，尿嘧啶和次黄嘌呤组成的核碱基]，一种式子为II的化合物：[其中B'是从腺嘌呤，鸟嘌呤，胞嘧啶，胸腺嘧啶，尿嘧啶和次黄嘌呤组成的核碱基]，一种合成这些核苷酸三磷酸盐的方法，以及使用这些核苷酸三磷酸盐生产寡核苷酸的过程。
• 4'-thionucleotide
  申请人：Matsuda Akira

  公开号：US20060127990A1

  公开（公告）日：2006-06-15

  Disclosed is a compound of formula I: [wherein B is a nucleobase selected from the group consisting of adenine, guanine, cytosine, uracil and hypoxanthine], a compound of formula II: [wherein B′ is a nucleobase selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and hypoxanthine], a method for synthesizing these nucleoside triphosphates, and a process for producing an oligonucleotide using these nucleoside triphosphates.

  本发明涉及一种化合物I的配方：[其中B是从腺嘌呤，鸟嘌呤，胞嘧啶，尿嘧啶和次黄嘌呤中选择的核苷碱]，一种化合物II的配方：[其中B'是从腺嘌呤，鸟嘌呤，胞嘧啶，胸腺嘧啶，尿嘧啶和次黄嘌呤中选择的核苷碱]，一种合成这些核苷酸三磷酸盐的方法，以及使用这些核苷酸三磷酸盐制备寡核苷酸的过程。
• Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production
  申请人：Herdewijn Piet

  公开号：US20070185062A1

  公开（公告）日：2007-08-09

  The present invention relates to novel phosponate nucleosides, more specifically to novel phosponalkoxy substituted nucleosides. The invention further relates to compounds having HIV (Human Immunodeficiency Virus) replication inhibiting properties and to compounds having antiviral activities with respect to other viruses. The invention also relates to methods for preparation of all such compounds and pharmaceutical compositions comprising them. The invention further relates to the use of said compounds as a medicine and in the manufacture of a medicament useful for the treatment of subjects suffering from HIV infection, as well as for treatment of other viral, retroviral or lentiviral infections and to the treatment of animals suffering from FIV, viral, retroviral or lentiviral infections.

  本发明涉及新型磷酸酯核苷，更具体地涉及新型磷酸酯烷氧基取代核苷。本发明还涉及具有抑制HIV（人类免疫缺陷病毒）复制作用的化合物，以及具有抗其他病毒活性的化合物。本发明还涉及制备所有这些化合物的方法和包含它们的制药组合物。本发明还涉及将所述化合物用作药物以及制造有用于治疗HIV感染患者的药物，以及用于治疗其他病毒、逆转录病毒或慢病毒感染和治疗患有FIV、病毒、逆转录病毒或慢病毒感染的动物的药物的用途。
• PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION
  申请人：Herdewijn Piet

  公开号：US20120108531A1

  公开（公告）日：2012-05-03

  Disclosed herein are novel phosphonate nucleosides and thiophosphonate nucleosides comprising a phosphonalkoxy-substituted or phosphonothioalkyl-substituted five-membered, saturated or unsaturated, oxygen-containing or sulfur-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base. The invention further relates to compounds having HIV (Human Immunodeficiency Virus) replication inhibiting properties and to compounds having antiviral activities with respect to other viruses. The invention also relates to methods for preparation of all such compounds and pharmaceutical compositions comprising them. The invention further relates to the use of said compounds as a medicine and in the manufacture of a medicament useful for the treatment of subjects suffering from HIV infection, as well as for treatment of other viral, retroviral or lentiviral infections and to the treatment of animals suffering from FIV, viral, retroviral or lentiviral infections.

  本文披露了一种新型磷酸酯核苷和硫代磷酸酯核苷，包括一个磷酸烷氧基取代或磷酸硫烷基取代的五元环，该环饱和或不饱和，含氧或含硫，与杂环核苷碱（如嘧啶或嘌呤碱基）结合。本发明还涉及具有HIV（人类免疫缺陷病毒）复制抑制性质的化合物，以及具有抗其他病毒活性的化合物。本发明还涉及制备所有这些化合物的方法和包含它们的药物组合物。本发明还涉及将所述化合物用作药物，并制造一种有用于治疗HIV感染患者以及治疗其他病毒、逆转录病毒或慢病毒感染和治疗患有FIV、病毒、逆转录病毒或慢病毒感染的动物的药物的药物。
• Jet printing ink compositions and method for their production
  申请人：VIDEOJET SYSTEMS INTERNATIONAL, INC.

  公开号：EP0510752B1

  公开（公告）日：1995-11-15