hydron;iodine-125(1-)

• 分子结构分类: 无机化合物 - 均质非金属化合物 - 卤代有机物
• 英文名称: hydron;iodine-125(1-)
• 化学式: HI
• 分子量: 125.9126
• InChiKey: XMBWDFGMSWQBCA-YPZZEJLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  1
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  1
• 氢受体数：
  0

ADMET

毒理性

• 在妊娠和哺乳期间的影响

◉ 母乳喂养期间使用总结：碘I-125暂时植入密封容器（贴片）中，以治疗局部肿瘤。在贴片放置期间，必须将母亲和婴儿分开，以避免婴儿受到辐射。母亲的乳汁不受影响，可以在稍后抽出并喂给婴儿。 ◉ 对哺乳婴儿的影响：截至修订日期，未找到相关的已发布信息。 ◉ 对泌乳和母乳的影响：一位正在哺乳11个月大婴儿的母亲因脉络膜黑色素瘤接受了碘I-125贴片治疗。在贴片放置的2天期间，她与婴儿分开，但为后续使用而抽出乳汁。在移除贴片后，恢复了哺乳。

◉ Summary of Use during Lactation:Iodine I-125 is implanted temporarily in a sealed container (plaque) to treat localized tumors. During the time that the plaque is in place, the mother and infant must be separated to avoid radiation exposure to the infant. The mother’s milk is not affected, and it can be pumped and fed to the infant at a later time. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:A mother nursing an 11-month-old infant was treated with an iodine I-125 plaque for uveal melanoma. The plaque was in place for 2 days during which time she was separated from her infant, but pumped milk for later use. Breastfeeding was resumed after plaque removal.

来源:Drugs and Lactation Database (LactMed)