Tilazol | 37291-85-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tilazol
• 英文别名: 2-(ethylamino)-2-thiophen-2-ylcyclohexan-1-one;4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride
• CAS: 37291-85-3
• 化学式: C27H33ClFN5O2S
• 分子量: 546.1
• InChiKey: KNRZNTXYCKLZIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Systems, apparatus, and methods for administering a substance
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US11185626B2

  公开（公告）日：2021-11-30

  Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

  本文介绍了施用物质的装置、工具包和方法。一种用于施用物质的装置包括一个具有近端和远端的细长体，细长体限定了一个在近端和远端之间延伸的内腔，用于将物质导向远端，远端与一个尖端连接，尖端至少部分插入受试者体腔的一个孔中，尖端具有一定的形状，用于在至少部分插入时减少物质从孔中的泄漏。尖端包括一个开口，用于将物质从内腔传入体腔；以及一个换能器，用于将超声波从尖端发射到体腔，从而将物质施用于体腔中的组织。
• SYSTEMS, APPARATUS, AND METHODS FOR ADMINISTERING A SUBSTANCE
  申请人：SCHOELLHAMMER Carl Magnus

  公开号：US20180055991A1

  公开（公告）日：2018-03-01

  Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.