Phosphohistidine | 4936-08-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Phosphohistidine
• 英文别名: (2S)-3-(1H-imidazol-5-yl)-2-(phosphonoamino)propanoic acid
• CAS: 4936-08-7
• 化学式: C₆H₁₀N₃O₅P
• 分子量: 235.13
• InChiKey: FDIKHVQUPVCJFA-YFKPBYRVSA-N

物化性质

• 沸点：
  689.0±65.0 °C(Predicted)
• 密度：
  1.764±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  136
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• [EN] PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES<br/>[FR] ANALOGUES DE LA PHOSPHOHISTIDINE ET DE LA PHOSPHOTYROSINE
  申请人：UNIV SHEFFIELD

  公开号：WO2015033120A1

  公开（公告）日：2015-03-12

  The invention relates to phosphohistidine analogues. The invention also relates to antibodies that specifically bind to the analogues and methods of generating said antibodies. In one embodiment of the invention there is provided a phosphohistidine analogue of Formula V: (V) wherein W is selected from H, CO2H or CONH2; and X is selected from CH or N.

  这项发明涉及磷酸组氨酸类似物。该发明还涉及特异性结合到这些类似物的抗体以及产生这些抗体的方法。在该发明的一个实施例中，提供了一种符合下式V的磷酸组氨酸类似物：(V)其中W从H、CO2H或CONH2中选择；X从CH或N中选择。
• PROTEIN PROXIMITY ASSAY IN FORMALIN FIXED PAFFAFIN EMBEDDED TISSUE USING CAGED HAPTENS
  申请人：Ventana Medical Systems, Inc.

  公开号：US20180186821A1

  公开（公告）日：2018-07-05

  Disclosed herein are caged haptens and caged hapten-antibody conjugates useful for enabling the detection of targets located proximally to each other in a sample.

  本文揭示了一种适用于检测样本中相互靠近的靶标的囚笼型半抗原和囚笼型半抗原-抗体结合物。
• [EN] PEPTIDE COMPOSITIONS FOR SLOWING DEGRADATION OF VITAMIN-MINERAL SUPPLEMENTS, FOODS, PHARMACEUTICALS, AND COSMETICS<br/>[FR] COMPOSITIONS PEPTIDIQUES POUR RALENTIR LA DÉGRADATION DE COMPLÉMENTS DE VITAMINES ET DE MINÉRAUX, D'ALIMENTS, DE PRODUITS PHARMACEUTIQUES ET COSMÉTIQUES
  申请人：BAILEY STEVEN W

  公开号：WO2019112630A1

  公开（公告）日：2019-06-13

  Compositions of foods, vitamin and mineral supplements, topical or oral drugs, and cosmetic products containing a small peptide or peptides for slowing degradation, for example by transition metals. The peptides are di, tri, terra-, and/or penta-peptides containing two or more aspartic acid residues. The degradation of several of the vitamin and other constituents vitamin-mineral supplements can be considerably slowed by composition incorporating such peptides, particularly if soluble (and thus bioavailable) forms of copper and/or iron are also present. The peptides can be hydrolyzed by the normal digestive process thus releasing bound metals. Multiple aspartate peptide(s) compositions with foods, topical or oral drugs, cosmetic, and hair care products can replace synthetic chelating preservative agents. Methods are also described to effectively slow degradation and preserve the above products using multiple aspartate peptides.

  食物、维生素和矿物质补充剂、局部或口服药物，以及含有小肽或肽的化妆品产品，用于减缓降解，例如通过过渡金属。这些肽是含有两个或更多天冬氨酸残基的二肽、三肽、四肽和/或五肽。通过含有这些肽的组合，可以显著减缓多种维生素和其他成分维生素矿物质补充剂的降解，特别是如果可溶（因此生物有效）的铜和/或铁的形式也同时存在。这些肽可以通过正常的消化过程水解，从而释放结合的金属。含有多个天冬氨酸肽的食品、局部或口服药物、化妆品和护发产品可以取代合成螯合防腐剂。还描述了使用多个天冬氨酸肽有效减缓降解和保持上述产品的方法。
• [EN] BENZOTHIOPHENE, BENZYLOXYBENZYLIDENE AND INDOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF TUBERCULOSIS<br/>[FR] BENZOTHIOPHÈNE, BENZYLOXYBENZYLIDÈNE ET DÉRIVÉS DE L'INDOLINE UTILES POUR LE TRAITEMENT DE LA TUBERCULOSE
  申请人：ECOLE POLYTECH

  公开号：WO2016041972A1

  公开（公告）日：2016-03-24

  The present invention relates to benzothiophene, benzyloxybenzylidene and indoline-2-one derivatives and the use of said derivatives in the treatment and/or prevention of tuberculosis.

  本发明涉及苯并噻吩、苄氧基苯甲醛亚甲基和吲哚啉-2-酮衍生物，以及该衍生物在结核病的治疗和/或预防中的应用。
• PHOSPHOHISTIDINE MIMETICS AND ANTIBODIES TO SAME
  申请人：THE TRUSTEES OF PRINCETON UNIVERSITY

  公开号：US20160311838A1

  公开（公告）日：2016-10-27

  Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. The invention is based in part on new pHis analogs that are chemically stable and which have been used as haptens and immunogens to generate specific anti-pHis antibodies that bind with high affinity and specificity.

  提供了基于磷酸吡唑基的磷酸组氨酸类似物，可用作制备免疫原的半抗原，包括将这些半抗原连接到载体分子的免疫原，以及与之相关的抗体和这些抗体、半抗原、免疫原和磷酸组氨酸类似物的用途。该发明部分基于新的pHis类似物，这些类似物在化学上是稳定的，并且已被用作半抗原和免疫原来产生特异性的抗pHis抗体，这些抗体具有高亲和力和特异性。