L-Tyrosine, N-(bromoacetyl)-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo- | 64379-24-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Tyrosine, N-(bromoacetyl)-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
• 英文别名: (2S)-2-[(2-bromoacetyl)amino]-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
• CAS: 64379-24-4
• 化学式: C₁₇H₁₂BrI₄NO₅
• 分子量: 897.8
• InChiKey: RZLOAUPCEMPCAE-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Verfahren zur Herstellung von reaktiven, kupplungsfähigen Derivaten der Schilddrüsenhormone T3 und T4 und deren Verwendung
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0049860A1

  公开（公告）日：1982-04-21

  Zur Herstellung von reaktiven, kupplungsfähigen Derivaten der Schilddrüsenhormone 3,3',5-Trijodthyronin (T3) und 3,3',5,5'-Tetrajodthyronin (T4) silyliert man sämtliche funktionellen Gruppen des Schilddrüsenhormons mit einem reaktiven Triorganosilyl-Derivat und setzt das erhaltene persilylierte Derivat des Schilddrüsenhormons mit einem aktivierten Carbonsäure-Derivat um. Die erhaltenen Verbindungen eignen sich zur Herstellung von unlöslichen Derivaten durch Kupplung mit polymeren Trägern oder Copolymerisation mit ungesättigten Monomeren.

  为了制备 3,3',5-三碘甲状腺原氨酸（T3）和 3,3',5,5'-四碘甲状腺原氨酸（T4）甲状腺激素的活性可偶联衍生物，甲状腺激素的所有官能团都要与活性三有机硅衍生物进行硅烷化反应，然后将得到的甲状腺激素过硅烷化衍生物与活性羧酸衍生物进行反应。得到的化合物适合通过与聚合物载体偶联或与不饱和单体共聚来制备不溶性衍生物。
• Assay methods utilizing induced luminescence
  申请人：BEHRINGWERKE Aktiengesellschaft

  公开号：EP0515194A2

  公开（公告）日：1992-11-25

  Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte; if present, causes a photosensitizer and a chemiluminescent compound to come into close proximity. The photosensitizer generates singlet oxygen and activates the chemiluminescent compound when it is in close proximity. The activated chemiluminescent compound subsequently produces light. The amount of light produced is related to the amount of analyte in the medium. Preferably, at least one of the photosensitizer and chemiluminescent compound is associated with a surface which is usually a suspendible particle, and a specific binding pair member is bound thereto. Another method comprises providing (1) a medium suspected of containing the analyte, (2) a label reagent comprising a first specific binding pair (sbp) member associated with a photochemically activatable chemiluminescent compound wherein the first sbp member is capable of binding to the analyte or to a second sbp member to form a complex related to the presence of the analyte. This method further comprises photochemically activating the chemiluminescent compound. The amount of luminescence generated by the chemiluminescent compound is detected. The amount thereof is related to the amount of analyte in the medium. Compositions and kits are also disclosed.

  本发明公开了测定疑似含有分析物的介质中分析物的方法。 其中一种方法包括处理疑似含有分析物的介质，处理条件是分析物（如果存在）会导致光敏剂和化学发光化合物接近。光敏剂产生单线态氧，并在靠近时激活化学发光化合物。被激活的化学发光化合物随后产生光。产生的光量与介质中分析物的含量有关。光敏剂和化学发光化合物中的至少一种最好与表面（通常是可悬浮颗粒）相关联，并与特定的结合对成员结合。 另一种方法包括：(1) 提供疑似含有分析物的介质；(2) 标签试剂，包括与光化学可激活的化学发光化合物相关的第一特异性结合对（sbp）成员，其中第一 sbp 成员能够与分析物或第二 sbp 成员结合，形成与分析物存在相关的复合物。该方法还包括光化学激活化学发光化合物。检测化学发光化合物产生的发光量。其数量与介质中分析物的数量相关。 此外，还公开了组合物和试剂盒。
• A homogeneous assay for determining analyte
  申请人：Dade Behring Marburg GmbH

  公开号：EP0984281A2

  公开（公告）日：2000-03-08

  Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing in combination (1) a medium suspected of containing an analyte; (2) a label reagent comprising a suspendible particle and a first specific binding pair (sbp) member associated with a photochemically activatable chemiluminescent compound (PACC), wherein said first sbp member is capable of binding to said analyte or to a second sbp member, wherein said second sbp member is capable of binding to said analyte; and (3) an intrinsically metastable species capable of diffusing in said medium and of reacting preferentially with said PACC when said PACC is brought into close proximity to said species by virtue of the presence or absence of said analyte; and determining whether said intrinsically metastable species has reacted with said PACC, the reaction thereof being related to the amount of analyte in said medium.

  本发明公开了用于确定疑似含有被分析物的介质中的被分析物的方法。 一种方法包括提供以下组合：(1) 被怀疑含有被分析物的介质；(2) 标签试剂，包括可悬浮颗粒和与光化学可激活化学发光化合物（PACC）相关的第一特异性结合对（sbp）成员，其中所述第一sbp成员能够与所述被分析物或第二sbp成员结合，其中所述第二sbp成员能够与所述被分析物结合；(3) 本征可转移物种，能够在所述介质中扩散，并且当所述 PACC 因所述分析物的存在或不存在而靠近所述物种时，能够优先与所述 PACC 反应；以及确定所述本征可转移物种是否与所述 PACC 反应，其反应与所述介质中分析物的量有关。
• FLUORESCENT OXYGEN CHANNELING IMMUNOASSAYS
  申请人：BEHRINGWERKE AG

  公开号：EP0716746A1

  公开（公告）日：1996-06-19
• Particles having an incorporated composition comprising a chemiluminescent compound
  申请人：Dade Behring Marburg GmbH

  公开号：EP0984282B1

  公开（公告）日：2003-07-30