2-(4-Hydroxytoluene-3-yl)-4,5-dihydro-4-carboxythiazole | 79173-80-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-Hydroxytoluene-3-yl)-4,5-dihydro-4-carboxythiazole
• 英文别名: 2-(2-hydroxy-5-methylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
• CAS: 79173-80-1
• 化学式: C₁₁H₁₁NO₃S
• 分子量: 237.28
• InChiKey: OEVXWWFLUUMMHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] ALTERNATIVE ACTIVATION OF MACROPHAGES (M2 CELLS) THROUGH THE POLYAMINE-eIF5a-HYPUSINE AXIS<br/>[FR] ACTIVATION ALTERNATIVE DE MACROPHAGES (CELLULES M2) PAR L'INTERMÉDIAIRE D'UN AXE POLYAMINE-EIF5A-HYPUSINE
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2018149978A1

  公开（公告）日：2018-08-23

  The present invention relates to a method for determining whether a compound has the capability of inhibiting elF5a activation, comprising (a) contacting a sample comprising cells being capable of differentiating into M2 macrophages with the compound under conditions that allow for the differentiation of cells into M2-type macrophages in the absence of the compound; and (b) quantifying in the sample the cells having a M2-phenotype, wherein a reduction of the number of cells having a M2-phenotype as compared to a control sample not contacted with the compound indicates that the compound has the capability of inhibiting elF5a activation.