1-(2-Ethoxy-2-oxoethyl)-6-methoxyquinolinium | 124505-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(2-Ethoxy-2-oxoethyl)-6-methoxyquinolinium
• 英文别名: ethyl 2-(6-methoxyquinolin-1-ium-1-yl)acetate
• CAS: 124505-60-8
• 化学式: C14H16NO3+
• 分子量: 246.28
• InChiKey: HEYSKURSHFYAMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] APPLICATION OF REDUCED DYES IN IMAGING<br/>[FR] APPLICATION DE COLORANTS RÉDUITS EN IMAGERIE
  申请人：LI COR INC

  公开号：WO2013044156A1

  公开（公告）日：2013-03-28

  The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots. In certain instances, the compounds are useful for detecting reactive oxygen species (ROS) probes for in vivo applications.

  本发明提供了从近红外青霉素染料衍生的新化合物和用于成像的氢氰染料的方法，作为反应性氧化物探针。在某些实施例中，本发明提供了作为ELISA和Western blots底物的还原染料。在某些情况下，这些化合物用于检测体内应用的反应性氧化物探针（ROS）。
• APPLICATION OF REDUCED DYES IN IMAGING
  申请人：LI-COR, INC.

  公开号：US20140213473A1

  公开（公告）日：2014-07-31

  The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.

  本发明提供了从近红外青菁染料衍生的新化合物和用于成像中作为反应性氧化物探针的方法。在某些实施例中，本发明提供了作为ELISA和Western blots底物的还原染料。
• ISOLATED SOLUBLE ALPHA-4 INTEGRIN, BETA-7 INTEGRIN AND ALPHA-4/BETA-7 HETERODIMER INTEGRIN
  申请人：Société des Produits Nestlé S.A.

  公开号：EP3536705A1

  公开（公告）日：2019-09-11

  The present invention provides a sensitive and specific indirect homogeneous mobility shift assay using size exclusion chromatography to measure biologics such as vedolizumab and ustekinumab in a patient sample. The assays of the present invention are particularly advantageous for detecting the presence or level of biologics that target complex or large antigens including cell surface proteins, transmembrane proteins, heavily glycosylated proteins, and multimeric proteins, as well as antigens that cannot be purified, impure antigens, and partially or substantially purified antigens. The present invention also provides isolated soluble α4β7 integrin heterodimers and isolated soluble IL-12p40 monomers that are suitable for use in the indirect assays described herein.

  本发明提供了一种使用尺寸排除色谱法的灵敏而特异的间接均相迁移率测定法，用于测定患者样本中的生物制剂，如维多单抗和乌司替尼。本发明的检测方法特别适用于检测针对复杂或大型抗原（包括细胞表面蛋白、跨膜蛋白、重糖基化蛋白和多聚蛋白）的生物制剂的存在或水平，以及无法纯化的抗原、不纯抗原和部分或基本纯化的抗原。本发明还提供了分离的可溶性α4β7整合素异二聚体和分离的可溶性IL-12p40单体，它们适合用于本文所述的间接测定。
• Directional surface plasmon coupled fluorescence and chemiluminescence from thin films of nickel, iron or palladium and uses thereof
  申请人：Geddes Chris D.

  公开号：US10024794B2

  公开（公告）日：2018-07-17

  Nickel, iron and palladium thin films thermally evaporated onto glass supports are used to demonstrate surface plasmon coupled fluorescence (SPCF) and surface plasmon couple chemiluminescence (SPCC) over a broad wavelength range (400-800 nm) for potential assays or other detection systems. Nickel, iron and palladium thin films used in SPCF and SPCC convert otherwise isotropic emission into highly directional and polarized emission, an attractive concept for surface assays. The emission angles of detected emissions occur over a 10 degree range for tested emitted wavelengths.

  热蒸发到玻璃支架上的镍、铁和钯薄膜被用于展示宽波长范围（400-800 nm）的表面等离子体耦合荧光（SPCF）和表面等离子体耦合化学发光（SPCC），以用于潜在的检测或其他检测系统。SPCF 和 SPCC 中使用的镍、铁和钯薄膜可将原本各向同性的发射转化为高度定向和极化的发射，这是表面检测的一个极具吸引力的概念。对于测试的发射波长，检测到的发射角在 10 度范围内。
• Ultra-fast pathogen toxin detection assay based on microwave-accelerated metal-enhanced fluorescence
  申请人：UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

  公开号：US10060923B2

  公开（公告）日：2018-08-28

  The present invention provides for a system and method to detect low levels of the anthrax protective antigen (PA) exotoxin in biological fluids, wherein the system uses a metal-enhanced fluorescence (MEF)-PA assay in combination with microwave-accelerated PA protein surface absorption. Microwave irradiation rapidly accelerates PA deposition onto the surface adjacent to deposited metallic particles and significantly speeding up the MEF-PA assay and resulting in a total assay run time of less than 40 min with an analytical sensitivity of less than 1 pg/ml PA.

  本发明提供了一种检测生物液体中低水平炭疽保护性抗原（PA）外毒素的系统和方法，其中该系统使用金属增强荧光（MEF）-PA 检测法，结合微波加速 PA 蛋白表面吸收。微波辐照可迅速加速 PA 在沉积金属颗粒附近表面的沉积，显著加快 MEF-PA 检测速度，使总检测时间小于 40 分钟，分析灵敏度小于 1 pg/ml PA。