Ferene disodium salt [5,5 inverted exclamation mark-(3-(2-Pyridyl)-1,2,4-triazine-5,6-diyl)-bis-2-furansulfonic acid,disodium salt]

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Ferene disodium salt [5,5 inverted exclamation mark-(3-(2-Pyridyl)-1,2,4-triazine-5,6-diyl)-bis-2-furansulfonic acid,disodium salt]
• 英文别名: disodium;5-[3-pyridin-2-yl-6-(5-sulfonatofuran-2-yl)-1,2,4-triazin-5-yl]furan-2-sulfonate
• 化学式: C16H8N4Na2O8S2
• 分子量: 494.4
• InChiKey: IVLSEFOVPQFJBB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.73
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  209
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• [EN] SMALL MOLECULE INHIBITORS OF THE BFRB:BFD INTERACTION<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE L'INTERACTION BFRB-BFD
  申请人：UNIV KANSAS

  公开号：WO2020117832A1

  公开（公告）日：2020-06-11

  The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.

  目前的技术提供了Formula I化合物以及相关方法，用于治疗细菌感染，以及抑制细菌铁蛋白和细菌铁蛋白相关的叶绿素蛋白之间的相互作用的方法。
• [EN] INHIBITORS OF THE BMP SIGNALING PATHWAY<br/>[FR] INHIBITEURS DE LA VOIE DE SIGNALISATION BMP
  申请人：GEN HOSPITAL CORP

  公开号：WO2009114180A1

  公开（公告）日：2009-09-17

  The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

  本发明提供了BMP信号通路的小分子抑制剂。这些化合物可用于调节细胞生长、分化、增殖和凋亡，因此可用于治疗与BMP信号通路相关的疾病或症状，包括炎症、心血管疾病、血液学疾病、癌症和骨骼疾病，以及调节细胞分化和/或增殖。
• [EN] AN IMMUNOREACTIVE 38-KDA FERRIC BINDING PROTEIN OF EHRLICHIA CANIS AND USES THEREOF<br/>[FR] PROTEINE DE LIAISON FERRIQUE 38-KDA IMMUNOREACTIVE DE EHRLICHIA CANIS ET SON UTILISATION
  申请人：RES DEV FOUNDATION

  公开号：WO2005082930A2

  公开（公告）日：2005-09-09

  The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric. binding protein (Fbp) (38-kDa) protein of Ehrlichia canis encoded by a polynucleotide therefor. In particular embodiments, the protein is employed in an immunogenic composition, such as a vaccine. Methods to induce an immune reaction in an individual with compositions of the invention are provided.

  本发明涉及克隆、测序、表达和表征由Ehrlichia canis的多核苷酸编码的一种免疫反应性铁结合蛋白（Fbp）（38-kDa）蛋白质。在特定实施例中，该蛋白质被用于免疫原性组合物，例如疫苗。本发明提供了使用该组合物诱导个体免疫反应的方法。
• INHIBITORS OF THE BMP SIGNALING PATHWAY
  申请人：Yu Paul B.

  公开号：US20110053930A1

  公开（公告）日：2011-03-03

  The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

  本发明提供了BMP信号通路的小分子抑制剂。这些化合物可以用于调节细胞生长、分化、增殖和凋亡，因此可能有用于治疗与BMP信号通路相关的疾病或病症，包括炎症、心血管疾病、血液疾病、癌症和骨骼疾病，以及调节细胞分化和/或增殖。
• Craze-resistant polysiloxane coating compositions containing a discontinuous phase; substrates coated therewith; process of producing the coatings on the substrates
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0001037A1

  公开（公告）日：1979-03-21

  Polysiloxane resin coatings containing a dispersed phase of particulate organic modifier which is tougher than the polysiloxane and which has an adequately high coefficient of friction have improved craze resistance permitting the use of thicker coatings with greater durability.

  聚硅氧烷树脂涂料中含有一种比聚硅氧烷更坚韧、摩擦系数足够高的微粒有机改性剂分散相，可以提高抗开裂性能，从而可以使用更厚、更耐用的涂料。