N-(Hydroxymethyl)-DL-methionine | 64226-78-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(Hydroxymethyl)-DL-methionine
• 英文别名: 2-(hydroxymethylamino)-4-methylsulfanylbutanoic acid
• CAS: 64226-78-4
• 化学式: C₆H₁₃NO₃S
• 分子量: 179.24
• InChiKey: WUNWNURVJGOTHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  94.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• FEED ADDITIVE FOR RUMINANT
  申请人：NIPPON SODA CO., LTD.

  公开号：EP0478783A1

  公开（公告）日：1992-04-08

  A feed additive for ruminant prepared by dispersing an active substance such as amino acids or vitamins in a protective substance mainly comprising metallic salts of fatty acid mixtures and granulating the dispersion and employed to allow the active substance to by pass the rumen to be digested and absorbed in the abomasum and the subsequent stomachs. It now becomes possible to well balance the active substance between the capability of by passing the rumen and the digestibility and absorbability in the abomasum and the subsequent stomachs.

  一种反刍动物饲料添加剂，将氨基酸或维生素等活性物质分散在主要由脂肪酸混合物的金属盐组成的保护物质中，然后将分散体颗粒化，使活性物质通过瘤胃，在腹腔和随后的胃中消化吸收。现在，可以在活性物质通过瘤胃的能力和在腹腔及随后胃中的消化吸收能力之间取得很好的平衡。
• Feed additive composition for ruminants
  申请人：Ajinomoto Co., Inc.

  公开号：EP0588346A2

  公开（公告）日：1994-03-23

  A feed additive composition containing a biologically active substance which is stable in the rumen of ruminants while allowing its efficient digestion and absorption in the abomasum and its subsequent digestive tract is provided. The feed additive composition for ruminants according to this invention is characterized in that a core which contains a biologically active substance is coated with a coating composition which contains at least a) and b) below. a) at least one substance selected from the group consisting of linear or branched saturated or unsaturated aliphatic monocarboxylic acids of 12-22 carbon atoms or salts thereof, hardened vegetable fats and oils, hardened animal fats and oils and wax; and b) a substance indicated in i) and/or ii) below. i) one or more linear or branched saturated or unsaturated aliphatic monocarboxylic acids or 11 carbon atoms or less, and ii) one or more substances selected from the group consisting of nucleic acids, nucleotides, nucleosides, bases composing nucleic acids and salts thereof.

  本发明提供了一种含有生物活性物质的饲料添加剂组合物，该生物活性物质在反刍动物的瘤胃中稳定，同时允许其在腹腔和随后的消化道中有效消化和吸收。 根据本发明的反刍动物饲料添加剂组合物，其特征在于含有生物活性物质的核心部分涂有涂层组合物，该涂层组合物至少包含以下a)和b)。 a) 至少一种物质，选自 12-22 碳原子的直链或支链饱和或不饱和脂肪族单羧酸或其盐、硬化植物油脂、硬化动物油脂和蜡组成的组；以及 b) 下文 i) 和/或 ii) 所述物质。 i) 一种或多种线性或支链饱和或不饱和脂肪族单羧酸，或 11 个碳原子或更少，和 ii) 一种或多种选自核酸、核苷酸、核苷、核酸碱及其盐类的物质。
• NOVEL COMPLEX SALTS OF PHOSPHORIC AND AMINO ACIDS AND RUMINANT FEED ADDITIVE COMPOSITION CONTAINING THE SAME
  申请人：Ajinomoto Co., Inc.

  公开号：EP0744396A1

  公开（公告）日：1996-11-27

  A novel phosphoric acid-amino acid complex salt is provided which manifests insolubility in a neutral or alkaline aqueous solution and solubility in an acidic aqueous solution and has a basic amino acid, an alkaline earth metal, and phosphoric acid as main components thereof. An additive composition containing the complex salt and used in a feed for ruminant mammals excels in protection in the first compartment of the stomach of a ruminant mammal and solubility in the fourth compartment of the stomach. This additive composition improves the nutrition of the feed with respect to such a basic amino acid as lysine, a substance frequently missing in the feed for ruminant mammals.

  本发明提供了一种新型磷酸-氨基酸复盐，它在中性或碱性水溶液中不溶解，在酸性水溶液中可溶解，其主要成分为碱性氨基酸、碱土金属和磷酸。含有该复合盐的添加剂组合物用于反刍哺乳动物的饲料中，在反刍哺乳动物胃的第一区段中具有出色的保护作用，在胃的第四区段中具有出色的溶解性。这种添加剂组合物改善了饲料中赖氨酸这种基本氨基酸的营养，而赖氨酸是反刍哺乳动物饲料中经常缺少的物质。
• Ruminant feed additive composition and process for producing the same
  申请人：Ajinomoto Co., Inc.

  公开号：EP0940088A2

  公开（公告）日：1999-09-08

  Disclosed herein are a ruminant feed additive composition containing (A) lysine magnesium phosphate, (B) magnesium oxide, (C) a binder and (D) water, said water content being between 5 and 15% by weight, and a process for producing the same. Such ruminant feed additive composition is an example of the ruminant feed additive composition where, when a ruminant feed additive contains a physiologically active substance, the physiologically active substance is fully protected in the rumen of a ruminant and rapidly dissolved in the abomasum, and which can easily be granulated by an extrusion-granulating method and the like. Disclosed herein is also a process for producing a ruminant feed additive composition, which comprises uniformly mixing (a) lysine magnesium phosphate, (b) magnesium oxide, (c) a meltable binder and (d) water required for extrusion granulation, subjecting this mixture to extrusion granulation at a temperature at which the meltable binder is not deteriorated, or uniformly mixing (a) lysine magnesium phosphate, (b) magnesium oxide and (c) a meltable binder, feeding this uniform powder mixture to an extrusion granulator for granulation while blowing (d) water before the die, drying the resulting granules under such conditions that the water contained therein is released as water vapor to render porous the structure of the particles and at the same time the pores are dipped with the molten binder present, and coating the surface of the dry particles with a coating agent, and a process for producing a ruminant feed additive composition, which comprises uniformly mixing (a) an amino acid, (b) an oily binder having a melting point of 40°C or more and (c) water required for extrusion granulation, and extrusion-granulating this mixture at the molten temperature of the above-mentioned oily binder, or uniformly mixing (a) an amino acid and (b) an oily binder having a melting point of 40°C or more, feeding this uniform powder mixture to an extrusion granulater at the molten temperature of the above-mentioned oily binder for granulation while blowing (c) water before the die, drying the resulting particles, and coating the surface of the dry particles with an oily coating agent to form the particles having a porosity of 20% or less, each providing a ruminant feed additive composition product of which the biochemical and physical properties (protection in the rumen and dissolution in the abomasum) are per se excellent, and which can be easily produced.

  本文公开了一种反刍动物饲料添加剂组合物，该组合物含有(A)赖氨酸磷酸镁、(B)氧化镁、(C)粘合剂和(D)水，所述水含量按重量计在5%至15%之间，以及生产该组合物的工艺。这种反刍动物饲料添加剂组合物是反刍动物饲料添加剂组合物的一个实例，当反刍动物饲料添加剂中含有生理活性物质时，生理活性物质在反刍动物的瘤胃中得到充分保护，并迅速溶解在腹腔中，而且很容易通过挤压造粒法等方法造粒。 本文还公开了一种反刍动物饲料添加剂组合物的生产工艺，该工艺包括将(a)赖氨酸磷酸镁、(b)氧化镁、(c)可熔化粘合剂和(d)挤压造粒所需的水均匀混合，在可熔化粘合剂不变质的温度下对该混合物进行挤压造粒，或将(a)赖氨酸磷酸镁、(b)氧化镁和(c)可熔化粘合剂均匀混合、将这种均匀的粉末混合物送入挤压造粒机进行造粒，同时在模头前吹 (d) 水，在这样的条件下干燥得到的颗粒，使其中所含的水以水蒸气的形式释放出来，使颗粒的结构多孔化，同时用存在的熔融粘结剂浸泡孔隙，并在干燥颗粒的表面涂上一层涂层剂，以及一种反刍动物饲料添加剂组合物的生产工艺、其中包括将(a)氨基酸、(b)熔点在 40℃以上的油性粘合剂和(c)挤压造粒所需的水均匀混合，并在上述油性粘合剂的熔融温度下对该混合物进行挤压造粒、或将(a)氨基酸和(b)熔点为 40℃或以上的油性粘合剂均匀混合，在上述油性粘合剂的熔融温度下将这种均匀的粉末混合物送入挤压造粒机造粒，同时在模头前吹入(c)水、干燥得到的颗粒，并在干燥颗粒的表面涂上油性涂层剂，以形成孔隙率为 20% 或更小的颗粒，从而提供一种反刍动物饲料添加剂组合物产品，其生化和物理性质（在瘤胃中的保护作用和在腹腔中的溶解作用）本身就很好，而且很容易生产。
• COMPOSITE SALT OF PHOSPHORIC AND AMINO ACIDS WITH POLYVALENT METALS AND FEED ADDITIVE COMPOSITION FOR RUMINANTS
  申请人：Ajinomoto Co., Inc.

  公开号：EP0937706A1

  公开（公告）日：1999-08-25

  The present specification discloses a ruminant feed additive composition which contains as an active ingredient a phosphoric acid-amino acid-polyvalent metal composite salt (final composite salt) which is insoluble in neutral or alkaline water and is soluble in acidic water and which can be obtained by treating a composite salt composed of a basic amino acid, magnesium and phosphoric acid with a salt of a divalent or trivalent (polyvalent) metal other than magnesium, or by treating the above-mentioned composite salt with the polyvalent metal salt and a condensed phosphoric acid component (alone) or the condensed phosphoric acid component and a phosphoric acid component (in combination), this composition taking the form of a powder or granules. The above-mentioned final composite salt can exhibit the excellent stability to neutral or slightly acidic water, namely, the low solubility therein in comparison with the intermediate composite salt, and it can have both the excellent insolubility of the basic amino acid in a rumen of a ruminant and the excellent elution thereof in an abomasum and lower digestive organs.

  本说明书公开了一种反刍动物饲料添加剂组合物，该组合物含有一种磷酸-氨基酸-多价金属复合盐（最终复合盐）作为活性成分，该复合盐不溶于中性或碱性水，可溶于酸性水，可通过处理由碱性氨基酸组成的复合盐而获得、镁和磷酸组成的复合盐与镁以外的二价或三价（多价）金属盐进行处理，或将上述复合盐与多价金属盐和缩合磷酸成分（单独）或缩合磷酸成分和磷酸成分（组合）进行处理，这种组合物呈粉末或颗粒状。与中间复合盐相比，上述最终复合盐对中性或微酸性水具有极佳的稳定性，即在其中的溶解度较低，而且它既能在反刍动物的瘤胃中具有极佳的碱性氨基酸不溶性，又能在腹腔和下消化器官中具有极佳的洗脱性。