[(3S)-3-氨基-4-[(3-己基苯基)氨基]-4-氧代丁基]膦酸 | 909725-63-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: [(3S)-3-氨基-4-[(3-己基苯基)氨基]-4-氧代丁基]膦酸
• 英文名称: [(3S)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]phosphonic acid
• 英文别名: [(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid
• CAS: 909725-63-9
• 化学式: C₁₆H₂₇N₂O₄P
• 分子量: 342.37
• InChiKey: FWJRVGZWNDOOFH-HNNXBMFYSA-N

物化性质

• 密度：
  1.233

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Liposomal formulation of nonglycosidic ceramides and uses thereof
  申请人：LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.

  公开号：US10039715B2

  公开（公告）日：2018-08-07

  The invention provides liposomes containing nonglycosidic ceramides within their bilayers, and compositions thereof. These liposomes activate murine iNKT cells and induce dendritic cell (DC) maturation, both in vitro and in vivo at an efficacy that is comparable to their corresponding soluble nonglycosidic ceramides. Also provided are methods for treating diseases using the liposomes and compositions of the invention.

  本发明提供了在其双层内含有非糖苷类神经酰胺的脂质体及其组合物。这些脂质体可在体外和体内激活小鼠 iNKT 细胞并诱导树突状细胞（DC）成熟，其功效与相应的可溶性非糖苷神经酰胺相当。此外，还提供了使用本发明脂质体和组合物治疗疾病的方法。
• LIPOSOMAL FORMULATION OF NONGLYCOSIDIC CERAMIDES AND USES THEREOF
  申请人：Ludwig Institute for Cancer Research, Ltd.

  公开号：EP2654779A1

  公开（公告）日：2013-10-30
• [EN] LIPOSOMAL FORMULATION OF NONGLYCOSIDIC CERAMIDES AND USES THEREOF<br/>[FR] FORMULATION LIPOSOMALE DE CÉRAMIDES NON-GLYCOSIDIQUES ET LEURS UTILISATIONS
  申请人：LUDWIG INST FOR CANCER RES LTD

  公开号：WO2012088414A1

  公开（公告）日：2012-06-28

  The invention provides liposomes containing nonglycosidic ceramides within their bilayers, and compositions thereof. These liposomes activate murine iNKT cells and induce dendritic cell (DC) maturation, both in vitro and in vivo at an efficacy that is comparable to their corresponding soluble nonglycosidic ceramides. Also provided are methods for treating diseases using the liposomes and compositions of the invention.