2,4-Thiazolidinedione, 5-((4-((3-hydroxy-1-methylcyclohexyl)methoxy)phenyl)methyl)- | 87858-57-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-Thiazolidinedione, 5-((4-((3-hydroxy-1-methylcyclohexyl)methoxy)phenyl)methyl)-
• 英文别名: 5-[[4-[(3-hydroxy-1-methylcyclohexyl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• CAS: 87858-57-9
• 化学式: C₁₈H₂₃NO₄S
• 分子量: 349.4
• InChiKey: AVOKTXBQCWLDRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• RXR AGONIST COMPOUNDS AND METHODS
  申请人：Case Western Reserve University

  公开号：EP2451455A2

  公开（公告）日：2012-05-16
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  公开（公告）日：2014-08-20
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  公开号：US20090042909A1

  公开（公告）日：2009-02-12

  A method of treating a dermatological disorder in a subject includes the step of administering a therapeutically effective amount of at least one PPARγ agonist or derivative thereof to the subject.
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  申请人：Davis Pamela B.

  公开号：US20090118337A1

  公开（公告）日：2009-05-07

  A method of treating a subject with a cystic fibrosis related disorder includes administering a therapeutically effective amount of at least one PPARγ agonist or a derivative thereof.
• METHODS AND COMPOSITIONS FOR TREATING CENTRAL NERVOUS SYSTEM TUMORS
  申请人：Landreth Gary E.

  公开号：US20100022600A1

  公开（公告）日：2010-01-28

  A method of treating a central nervous system tumor in a subject includes administering a therapeutically effective amount of at least one PPARγ agonist or a derivative thereof to the tumor in the subject.