S-(6-Purinyl)-N-acetylcysteine | 136039-99-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-(6-Purinyl)-N-acetylcysteine
• 英文别名: (2R)-2-acetamido-3-(7H-purin-6-ylsulfanyl)propanoic acid
• CAS: 136039-99-1
• 化学式: C₁₀H₁₁N₅O₃S
• 分子量: 281.29
• InChiKey: JNURDKXJPBZZGO-LURJTMIESA-N

物化性质

• 密度：
  1.69±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Prodrugs of 6-mercaptopurine and 6-thioguanine
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：EP0426467A1

  公开（公告）日：1991-05-08

  Prodrugs for the treatment of kidney tumors are disclosed. The prodrugs are conjugates that can require the cooperation of multiple enzymes in the kidney to release 6-­mercaptopurine or 6-thioguanine, or can selectively release 6-thioguanine. The prodrugs have the formula: wherein R₁ is H or NH₂, x is 1 or 2 and R₂ represents various carboxylic acid or ester groupings, generally containing an animo and/or amido group.

  本研究公开了用于治疗肾脏肿瘤的原药。这些原药是共轭物，可以需要肾脏中多种酶的合作来释放 6-巯基嘌呤或 6-硫鸟嘌呤，或者可以选择性地释放 6-硫鸟嘌呤。这些原药的结构式如下 其中，R₁ 是 H 或 NH₂，x 是 1 或 2，R₂ 代表各种羧酸或酯基，通常含有阿米诺和/或氨基。
• COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS
  申请人：Dentalmed Pharm Holding Ltd.

  公开号：EP2976061B1

  公开（公告）日：2019-10-16
• US5120740A
  申请人：——

  公开号：US5120740A

  公开（公告）日：1992-06-09
• [EN] COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS<br/>[FR] COMBINAISON DE DÉRIVÉS DE N-ACÉTYLCYSTÉINE ET DE POLYPHÉNOLS DE CANNEBERGE DANS DES COMPOSITIONS ET DES PROCÉDÉS POUR PRÉVENIR ET TRAITER DES MALADIES PARODONTIQUES ET UNE PÉRI-IMPLANTITE
  申请人：DENTALMED PHARM HOLDING LTD

  公开号：WO2014147613A1

  公开（公告）日：2014-09-25

  The present invention relates to combined compositions comprising a combination of N-acetyl cysteine (NAC), or any derivatives thereof, and polyphenols, specifically cranberry polyphenols. The invention further provides methods and uses of said combined compositions for treating and preventing periodontal diseases, specifically gingivitis, periodontitis and peri-implantitis.
• [EN] COMPOSITIONS AND METHODS FOR TREATING OSTEOLYSIS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE L'OSTÉOLYSE
  申请人：UNIV RAMOT

  公开号：WO2021181379A1

  公开（公告）日：2021-09-16

  The present invention relates to methods for treating inflammation-induced and/or aseptic osteolysis. In particular, the methods comprise the use of analogs of vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase activating polypeptide (PACAP) in osteolysis in periodontal or other diseases and conditions.