1-(4-ethoxy-benzyl)-dihydro-pyrimidine-2,4-dione | 55383-99-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(4-ethoxy-benzyl)-dihydro-pyrimidine-2,4-dione
• 英文别名: 2,4(1H,3H)-Pyrimidinedione, dihydro-1-((4-ethoxyphenyl)methyl)-；1-[(4-ethoxyphenyl)methyl]-1,3-diazinane-2,4-dione
• CAS: 55383-99-8
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: AXXKQDRYWZMKRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(4-Ethoxy-benzylamino)-propionic acid methyl ester 、 尿素 以66%的产率得到
  参考文献：
  名称：

  KALDRIKYAN M. A.; AROYAN A. A., AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH. , 1974, 27, HO 12, 1031-+

  摘要：

  DOI：

文献信息

• Change of the Load State of Mhc Molecules
  申请人：Falk Kirsten

  公开号：US20070280957A1

  公开（公告）日：2007-12-06

  The present invention relates to methods for changing the load state of MHC molecules with ligands, the change in the load state being catalysed by a compound of formulae I, IA, II, III or IV1 to IV3. The invention relates further to the use of compounds of formulae I, IA, II, III or IV1 to IV3 or to the use of MHC molecules loaded with ligands, which molecules can be prepared by a method according to the invention, for the treatment of disorders or conditions that are associated with various pathologically excessive or absent immune responses and also for triggering tumour-specific, pathogen-specific or autoreactive immune responses. The invention additionally relates to the use of such compounds for the treatment and diagnosis of cancer, infectious diseases, autoimmune diseases and for attenuating aggressive immune reactions, as well as to the preparation of a vaccine or of a pharmaceutical composition for the treatment of the mentioned disorders or conditions.
• KALDRIKYAN M. A.; AROYAN A. A., AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH. <AUKZ-AN>, 1974, 27, HO 12, 1031-+
  作者：KALDRIKYAN M. A.、 AROYAN A. A.

  DOI：——

  日期：——