laminine | 28101-37-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: laminine
• 英文别名: ε-N,N,N-trimethyllysine；laminin；DL-N-Trimethyllysin；ε-N-Trimethyllysin；DL-(5-Amino-5-carboxy-pentyl)-trimethylammonium；Trimethyl-(5-amino-5-carboxy-pentyl)-ammonium；(5-Amino-5-carboxy-pentyl)-trimethylammonium；2-Amino-6-trimethylammonio-capronsaeure；N-Trimethyllysin；DL-Trimethyllysine；2-Azaniumyl-6-(trimethylazaniumyl)hexanoate
• CAS: 28101-37-3
• 化学式: C₉H₂₁N₂O₂
• 分子量: 189.278
• InChiKey: MXNRLFUSFKVQSK-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  邻苯二甲醛 、 laminine 生成 [(5S)-5-carboxy-5-isoindol-2-ylpentyl]-trimethylazanium
  参考文献：
  名称：

  PARK, KWANG SOOK;LEE, HYANG WOO;HONG, SUNG-YOUL;SHIN, SOOK;KIM, SANGDUK;P+, J. CHROMATOGR., 440,(1988) 225-230

  摘要：

  DOI：

文献信息

• PARK, KWANG SOOK;LEE, HYANG WOO;HONG, SUNG-YOUL;SHIN, SOOK;KIM, SANGDUK;P+, J. CHROMATOGR., 440,(1988) 225-230
  作者：PARK, KWANG SOOK、LEE, HYANG WOO、HONG, SUNG-YOUL、SHIN, SOOK、KIM, SANGDUK、P+

  DOI：——

  日期：——
• AMMONIUM DERIVATIVES FOR THE TREATMENT OF HEPATITIS C
  申请人：Bristol-Myers Squibb Company

  公开号：EP2948151B1

  公开（公告）日：2017-05-31
• DISEASE DETECTION AND TREATMENT BASED ON TRIMETHYL-LYSINE LEVELS
  申请人：The Cleveland Clinic Foundation

  公开号：EP3746066A1

  公开（公告）日：2020-12-09
• DISEASE DETECTION AND TREATMENT BASED ON PHENYLACETYL GLUTAMINE LEVELS
  申请人：The Cleveland Clinic Foundation

  公开号：EP4100541A1

  公开（公告）日：2022-12-14
• Method of synthesis and purification of N-6-Trimethyl-L-Lysine and derivative compounds
  申请人：Srivastava Suresh C.

  公开号：US20110166379A1

  公开（公告）日：2011-07-07

  The invention provides a method of synthesis of N-6-trimethyl-L-lysine (TML) derivative compounds for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method of purification of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent application.