Isobutyl(metha)acrylate | 158576-95-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Isobutyl(metha)acrylate
• 英文别名: 2,5-dimethylhex-2-enoic acid
• CAS: 158576-95-5
• 化学式: C₈H₁₄O₂
• 分子量: 142.2
• InChiKey: BLCHIKLQYBVYAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] CARBIDOPA PRODRUGS AND USES THEREOF<br/>[FR] PROMEDICAMEMTS DE CARBIDOPA ET LEURS UTILISATIONS
  申请人：XENOPORT INC

  公开号：WO2004052841A1

  公开（公告）日：2004-06-24

  Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed.

  卡比多巴的前药、卡比多巴前药的衍生物、卡比多巴及其衍生物前药的制作方法、卡比多巴及其衍生物前药的使用方法以及卡比多巴及其衍生物前药的组合物被公开。
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US20140235634A1

  公开（公告）日：2014-08-21

  Described herein are compounds of Formula (I) or Formula (VI), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I) or Formula (VI) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating diseases are also provided.

  本文描述了公式（I）或公式（VI）的化合物，其药学上可接受的盐以及其药物组合物。还提供了包含公式（I）或公式（VI）化合物及其药物组合物的微粒（例如，纳米颗粒），这些微粒具有穿透黏液的特性。还提供了使用这些化合物或药物组合物治疗疾病的方法。
• NANOSCALE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Sengupta Shiladitya

  公开号：US20120189571A1

  公开（公告）日：2012-07-26

  The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.

  这项发明涉及生物相容性共轭聚合物纳米颗粒，包括一个共聚物骨架，多个共价连接到该骨架的侧链，以及多个可解离地连接到该骨架的铂化合物。该发明还涉及二羰基脂类化合物，其中铂化合物可可解离地连接到二羰基化合物。该发明还涉及治疗癌症或转移的方法。该方法包括选择需要癌症或转移治疗的受试者，并向受试者施用该发明的任何纳米颗粒、化合物或组合物的有效量。
• EUROPIUM COMPLEX
  申请人：TOSOH CORPORATION

  公开号：US20200354389A1

  公开（公告）日：2020-11-12

  To provide europium complexes having high photostability. A europium complex expressed with the following formula (A): wherein, R A and R B are independently a cyclic alkyl group with 3 to 10 carbons, respectively, and R C is a cyclic alkyl group with 3 to 10 carbons or a phenyl group expressed with the following formula (B): (wherein, X A , X B , A C , X D and X E independently represent a hydrogen atom; a fluorine atom; an alkyl group with 1 to 3 carbon(s); an alkyloxy group with 1 to 3 carbon(s); an aryloxy group with 6 to 10 carbons; a fluoroalkyl group with 1 to 3 carbon(s); a fluoroalkyloxy group with 1 to 3 carbon(s); or a phenyl group that may be substituted with a fluorine atom, an alkyl group with 1 to 3 carbon(s), an alkyloxy group with 1 to 3 carbon(s), a fluoroalkyl group with 1 to 3 carbon(s), a fluoroalkyloxy group with 1 to 3 carbon(s), a fluorophenyl group, a hydroxyl group or a cyano group, respectively); R A is a cyclic alkyl group with 3 to 10 carbons; R B and R C are a phenyl group expressed with the formula (B), provided, however, that a case where R A a cyclohexyl group, and, R B and R C are a phenyl group is excluded; or R A , R B and R C independently represent an ortho-substituted phenyl group expressed with the following formula (Ba): (wherein, X E represents a hydrogen atom, an alkyl group with 1 to 3 carbon(s), an alkyloxy group with 1 to 3 carbon(s), a fluoroalkyl group with 1 to 3 carbon(s), a fluoroalkyloxy group with 1 to 3 carbon(s), a naphthyl group that may be substituted with a fluorine atom, a pyridyl group that may be substituted with a fluorine atom, or a phenyl group that is expressed with a formula (C): [wherein, Z A , Z C and Z E independently represent a hydrogen atom, a fluorine atom, an alkyl group with 1 to 3 carbon(s), an alkyloxy group with 1 to 3 carbon(s), a fluoroalkyl group with 1 to 3 carbon(s), a fluoroalkyloxy group with 1 to 3 carbon(s), a phenyl group that may be substituted with a fluorine atom, a hydroxyl group or a cyano group; Z B and Z D independently represent a hydrogen atom or a fluorine atom, respectively], provided, however, that a case where R A , R B and R C are all a phenyl group is excluded), respectively; R D represents a hydrogen atom, a deuterium atom or a fluorine atom; W A and W B independently represent an alkyl group with 1 to 6 carbon(s), a fluoroalkyl group with 1 to 6 carbon(s), a phenyl group, a 2-thienyl group or a 3-thienyl group; and ‘n’ represents an integer of 1 to 3}.

  提供具有高光稳定性的铕配合物。 以下是用以下公式（A）表示的铕配合物： 其中，R A 和R B 分别独立地是具有3至10个碳原子的环烷基基团，而R C 是具有3至10个碳原子的环烷基基团或用以下公式（B）表示的苯基团： （其中，X A 、X B 、A C 、X D 和X E 独立地代表氢原子；氟原子；具有1至3个碳原子的烷基基团；具有1至3个碳原子的烷氧基团；具有6至10个碳原子的芳基氧基团；具有1至3个碳原子的氟烷基基团；具有1至3个碳原子的氟烷氧基团；或者可能被氟原子、具有1至3个碳原子的烷基基团、具有1至3个碳原子的烷氧基团、具有1至3个碳原子的氟烷基基团、具有1至3个碳原子的氟烷氧基团、氟苯基团、羟基或氰基取代的苯基团，分别）； R A 是具有3至10个碳原子的环烷基基团； R B 和R C 是用公式（B）表示的苯基团，但是，排除R A 为环己基团，且R B 和R C 为苯基团的情况；或者 R A ，R B 和R C 独立地表示用以下公式（Ba）表示的邻位取代的苯基团： （其中，X E 代表氢原子、具有1至3个碳原子的烷基基团、具有1至3个碳原子的烷氧基团、具有1至3个碳原子的氟烷基基团、具有1至3个碳原子的氟烷氧基团、可能被氟原子取代的萘基团、可能被氟原子取代的吡啶基团，或者用以下公式（C）表示的苯基团： [其中，Z A 、Z C 和Z E 独立地代表氢原子、氟原子、具有1至3个碳原子的烷基基团、具有1至3个碳原子的烷氧基团、具有1至3个碳原子的氟烷基基团、具有1至3个碳原子的氟烷氧基团、可能被氟原子取代的苯基团、羟基或氰基；Z B 和Z D 独立地代表氢原子或氟原子，但排除R A ，R B 和R C 都是苯基团的情况），分别；R D 代表氢原子、氘原子或氟原子；W A 和W B 独立地表示具有1至6个碳原子的烷基基团、具有1至6个碳原子的氟烷基基团、苯基、2-噻吩基团或3-噻吩基团；‘n’表示1至3的整数。
• Thermotropic liquid crystal polymer microcapsules, a method for preparing the same, and cosmetic compositions containing the same
  申请人：——

  公开号：US20030129247A1

  公开（公告）日：2003-07-10

  There are provided thermotropic liquid crystal polymer microcapsules which can show behavior of liquid crystal as it is within polymer phase due to phase separation between liquid crystal and polymer, so to be incorporated into cosmetic composition as an additive for visual effect, and in loading active ingredients within liquid crystal, can improve the stability of the active ingredients in cosmetic base; and a method for preparing the same; and cosmetic compositions containing the same.

  提供了热致液晶聚合物微胶囊，由于液晶与聚合物之间的相分离，这些微胶囊可以展现液晶在聚合物相中的行为，因此可以作为化妆品组合物中的添加剂用于视觉效果，并且在液晶中装载活性成分，可以提高这些活性成分在化妆品基料中的稳定性；以及制备这些微胶囊的方法；以及含有这些微胶囊的化妆品组合物。