(E)-N-methyloctadec-9-enamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-N-methyloctadec-9-enamide
• 化学式: C₁₉H₃₇NO
• 分子量: 295.5
• InChiKey: NJNFUPWMCKHLRE-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：US20210052631A1

  公开（公告）日：2021-02-25

  Provided herein are oligomeric compounds comprising a modified oligonucleotide and a conjugate group for modulating the amount or activity of a target nucleic acid in extra hepatic tissues and extra hepatic cells. Also provided herein are methods of modulating the amount or activity of an extra-hepatic nucleic acid target in a cell comprising contacting the cell with the oligomeric compound or antisense compound.