Caerulein(4-10), nle(8)- | 25613-79-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Caerulein(4-10), nle(8)-
• 英文别名: (3S)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2R)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-amino-3-(4-sulfooxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-4-oxobutanoic acid
• CAS: 25613-79-0
• 化学式: C₄₅H₅₇N₉O₁₄S
• 分子量: 980.1
• InChiKey: GZCDGEPFXQGWOW-RMNOTBJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  69
• 可旋转键数：
  27
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  389
• 氢给体数：
  12
• 氢受体数：
  15

文献信息

• Combinatorial analysis and repair
  申请人：Pedersen Henrik

  公开号：US10722562B2

  公开（公告）日：2020-07-28

  A method for the repair of a unit, by specific diagnosis of the undesired state, and its appropriate repair, using said specific diagnosis as a means to repair in an appropriate way said unit. The diagnosis and repair processes may involve chemical, physical, or mechanical means. The units being diagnosed and repaired include live matter (e.g. human beings, animals, plants) as well as non-live matter (e.g. buildings, electronic equipment, polymer materials).

  通过对不希望出现的状态进行特定诊断，并利用所述特定诊断作为以适当方式修复所述装置的手段，对装置进行适当修复的方法。诊断和修复过程可能涉及化学、物理或机械手段。被诊断和修复的单元包括活体（如人类、动物、植物）和非活体（如建筑物、电子设备、高分子材料）。
• SR-BI nucleic acids and uses therefor
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20030023059A1

  公开（公告）日：2003-01-30

  The present invention is based at least in part on the discovery of the genomic structure of the human SR-BI gene and on the identification of polymorphic regions within the gene. Accordingly, the invention provides nucleic acids having a nucleotide sequence of an allelic variant of an SR-BI gene and nucleic acids having an SR-BI intronic sequence. The invention also provides methods for identifying specific alleles of polymorphic regions of an SR-BI gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an SR-BI gene, and kits for performing such methods.

  本发明至少部分基于对人类 SR-BI 基因的基因组结构的发现以及对该基因内多态区的鉴定。因此，本发明提供了具有 SR-BI 基因等位基因变体核苷酸序列的核酸和具有 SR-BI 内含子序列的核酸。本发明还提供了鉴定 SR-BI 基因多态区特定等位基因的方法、确定受试者是否患有或有可能患上与 SR-BI 基因多态区特定等位基因有关的疾病的方法，以及用于实施这些方法的试剂盒。
• Diagnostic assays and kits for body mass and cardiovascular disorders
  申请人：——

  公开号：US20030044782A1

  公开（公告）日：2003-03-06

  The present invention is based at least in part on the discovery of the genomic structure of the human SR-BI gene and on the identification of polymorphic regions within the gene. Accordingly, the invention provides nucleic acids having a nucleotide sequence of an allelic variant of an SR-BI gene and nucleic acids having an SR-BI intronic sequence. The invention also provides methods for identifying specific alleles of polymorphic regions of an SR-BI gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an SR-BI gene, and kits for performing such methods.

  本发明至少部分基于对人类 SR-BI 基因的基因组结构的发现以及对该基因内多态区的鉴定。因此，本发明提供了具有 SR-BI 基因等位基因变体核苷酸序列的核酸和具有 SR-BI 内含子序列的核酸。本发明还提供了鉴定 SR-BI 基因多态区特定等位基因的方法、确定受试者是否患有或有可能患上与 SR-BI 基因多态区特定等位基因有关的疾病的方法，以及用于实施这些方法的试剂盒。
• US5998141A
  申请人：——

  公开号：US5998141A

  公开（公告）日：1999-12-07
• US6030778A
  申请人：——

  公开号：US6030778A

  公开（公告）日：2000-02-29