2-methoxycarbonylmethylthioethylamine hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methoxycarbonylmethylthioethylamine hydrochloride
• 英文别名: hydron;methyl 2-(2-aminoethylsulfanyl)acetate;chloride
• 化学式: C₅H₁₁NO₂S*ClH
• mdl: MFCD17977054
• 分子量: 185.675
• InChiKey: LBYBMKYIAODETE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.52
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  77.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  carboxymethylcysteamine 、 2,2-二甲氧基丙烷 、 盐酸 在 乙酸乙酯 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以The flakes formed (17.5 g)的产率得到2-methoxycarbonylmethylthioethylamine hydrochloride
  参考文献：
  名称：

  Cysteamine derivatives for oral treatment of seborrhea

  摘要：

  一种治疗头皮油脂分泌过多的方法，通过减少过多分泌来改善其状况，包括口服给予一种治疗组合物，该组合物包括可食用载体和半胱氨酸或半胱氨酸衍生物作为无毒活性化合物，所述活性化合物的含量为该组合物的0.75-3重量百分比，按照人体重量每天1-5毫克/千克的速率在约15天的时间内给予头皮油脂分泌过多的人类。

  公开号：

  US03950542A1

文献信息

• Process and cosmetic compositions for the treatment of skin and scalp
  申请人：L'Oreal

  公开号：US03976781A1

  公开（公告）日：1976-08-24

  A method, composition and compounds useful in said compositions for treating the skin and scalp characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum includes topically applying to a human having skin and/or a scalp so characterized a cosmetic composition containing as an active ingredient a derivative of cysteine or cysteamine. The composition contains about 0.1-5 weight percent of said derivative and also contains as a carrier for the active ingredient, water, a mixture of water and a lower alkanol, a lower alkanol, a mixture of a lower alkanol and a cosmetic resin, a reducing agent, a neutralizing agent or a vegetable oil.

  一种用于治疗皮肤和头皮分泌过多皮脂的方法、组合物和化合物，用于通过减少皮脂的过度分泌来改善其状况，包括将含有半胱氨酸或半胱氨酸衍生物的活性成分的化妆品组合物局部涂抹在具有该特征的人类皮肤和/或头皮上。该组合物含有约0.1-5重量％的该衍生物，并且还包含作为活性成分的载体，水，水和低碳醇的混合物，低碳醇，低碳醇和化妆品树脂的混合物，还包含还原剂，中和剂或植物油。
• Sulfur containing heterocyclic amino acid derivatives
  申请人：L'Oreal

  公开号：US04204064A1

  公开（公告）日：1980-05-20

  A method, composition and compounds useful in said compositions for treating the skin and scalp characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum includes topically applying to a human having skin and/or a scalp so characterized a cosmetic composition containing as an active ingredient a derivative of cysteine or cysteamine. The composition contains about 0.1-5 weight percent of said derivative and also contains as a carrier for the active ingredient, water, a mixture of water and a lower alkanol, a lower alkanol, a mixture of a lower alkanol and a cosmetic resin, a reducing agent, a neutralizing agent or a vegetable oil.

  一种用于治疗皮肤和头皮过度分泌皮脂的方法，组合物和有用于所述组合物的化合物，通过减少皮脂的过度分泌来改善其状况，包括局部应用含有半胱氨酸或半胱氨酸衍生物作为活性成分的化妆品组合物于具有上述特征的人类皮肤和/或头皮上。该组合物含有约0.1-5重量％的该衍生物，并且还含有作为活性成分载体的水，水和低级烷醇的混合物，低级烷醇，低级烷醇和化妆品树脂的混合物，还含有还原剂，中和剂或植物油。
• Oral treatment of seborrhea with cysteamine derivatives
  申请人：L'Oreal

  公开号：US04035492A1

  公开（公告）日：1977-07-12

  A method for treating a scalp characterized by an excessive secretion of sebum, to improve the condition thereof by reducing said excessive secretion comprising orally administering to a human being having a scalp so characterized a therapeutic composition comprising an ingestible carrier admixed with, as a non-toxic active compound, cysteine or cysteamine derivatives, the active compound is present in amounts of about 0.75-3 weight percent of the composition which is administered at a rate of about 1-5 mg/kg/day based on the weight of the human being during a period of about 15 days.

  一种治疗头皮分泌过多皮脂的方法，通过减少过多的皮脂分泌来改善其状况，包括口服给予一种治疗性组合物，该组合物包括可食用载体和半胱氨酸或半胱氨酸衍生物作为无毒活性化合物，该活性化合物占组合物重量的约0.75-3％，按照人体重量每天1-5毫克/千克的速率在约15天的时间内给予头皮过度分泌皮脂的人类。
• Microparticles
  申请人：NovaBiotics Limited

  公开号：US10905660B2

  公开（公告）日：2021-02-02

  The present invention provides microparticles comprising a sulphur-containing compound, such as cysteamine, or a pharmaceutically acceptable salt, hydrate or ester thereof. Also provided is a composition comprising the microparticles and a stabilizing agent.

  本发明提供了包含半胱胺等含硫化合物或其药学上可接受的盐、水合物或酯的微颗粒。本发明还提供了一种包含微颗粒和稳定剂的组合物。
• Microparticles comprising a sulphur-containing compound
  申请人：NOVABIOTICS LIMITED

  公开号：US11369568B2

  公开（公告）日：2022-06-28

  The present invention provides microparticles comprising a sulphur-containing compound, such as cysteamine, or a pharmaceutically acceptable salt, hydrate or ester thereof. Also provided is a composition comprising the microparticles and a stabilizing agent.

  本发明提供了包含半胱胺等含硫化合物或其药学上可接受的盐、水合物或酯的微颗粒。本发明还提供了一种包含微颗粒和稳定剂的组合物。