ethyl α-methyl-γ-piperidinobutyrate | 49637-22-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl α-methyl-γ-piperidinobutyrate
• 英文别名: ethyl-2-methyl-4-piperidinobutyrate；2-methyl-4-piperidin-1-yl-butyric acid ethyl ester；Ethyl 2-methyl-4-piperidinobutyrate；ethyl 2-methyl-4-piperidin-1-ylbutanoate
• CAS: 49637-22-1
• 化学式: C₁₂H₂₃NO₂
• 分子量: 213.32
• InChiKey: BATCSNGUUOOSBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl α-methyl-γ-piperidinobutyrate 在 盐酸 作用下， 以 乙醚 、 水 为溶剂， 生成 α-methyl-γ-piperidinobutyric acid hydrochloride
  参考文献：
  名称：

  Novel heterocyclic esters of benzopyranopyridines

  摘要：

  这是一个关于苯并吡啶酮的新型杂环酯的化学式，其表示为## STR1 ##其中R.sub.1为氢，低烷基，低酰基，环烷基-低烷基，环烷基-低酰基，低烯基，低炔基，卤代-低烯基，苯基-低烷基，苯基-低烯基或苯基-低炔基；R.sub.2为低烷基；R.sub.3为具有一到二十个碳原子的烷基或环烷基-低烷基；Y为具有一到八个碳原子的直链或支链烷基；R.sub.4为## STR2 ##其中a为1到4的整数，b为1到4的整数，X为CH.sub.2，O，S或N--R.sub.5，其中R.sub.5为氢或低烷基，但当X为O，S或N--R.sub.5时，a和b必须各为2，R.sub.6为氢或连接到环中碳原子的低烷基基团；以及它们的酸加合物盐。

  公开号：

  US04042694A1
• 作为产物：
  描述：

  4-溴-2-甲基丁酸乙酯 、 哌啶 以 苯 为溶剂， 反应 20.0h， 生成 ethyl α-methyl-γ-piperidinobutyrate
  参考文献：
  名称：

  Anesthesia methods using benzopyrans and esters thereof as

  摘要：

  改进的麻醉方法包括使用式I的苯并吡喃预处理待麻醉的患者，其中在C环中，X为NR.sub.1，S，CH.sub.2或##STR2##，R.sub.1为氢，低烷基，低烯基，低炔基，低酰基，环烷基低烷基，环烷基低酰基，环烷基，卤代低烷基，卤代低烯基，苯基低烷基，苯基低烯基或苯基低烷基基；m为0至3的整数，n为0至3的整数，n + m = 2或3；或C环为喹啉环##STR3##，R.sub.2为低烷基；R.sub.3为氢或##STR4##，其中Y为直链或支链烷基链，具有1至8个碳原子，a为1至4的整数，b为1至4的整数，Z为CH.sub.2，O，S或NR.sub.6，其中R.sub.6为氢或低烷基，限制条件为当Z为O，S或NR.sub.5时，a和b的和为3或4，R.sub.5为氢或低烷基；R.sub.4为C.sub.1-C.sub.20直链或支链烷基，环烷基，或##STR5##，其中Y为具有1至10个碳原子的直链或支链烷基链，每个R.sub.7，R.sub.8和R.sub.9是相同或不同的羟基，卤素，三氟甲基或低烷基成员的群；及其药学上可接受的盐，限制条件为当X为##STR6##时，m = 2且n = 2时，R.sub.3不能为氢。

  公开号：

  US04025630A1

文献信息

• [EN] ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS<br/>[FR] INHIBITEURS DE RÉCEPTEURS NICOTINIQUES ALPHA-7 DE L'ACÉTYLCHOLINE
  申请人：WYETH CORP

  公开号：WO2010009290A1

  公开（公告）日：2010-01-21

  The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory systems.

  本发明提供了化合物和组合物，制备它们的方法，以及利用它们调节α7烟碱乙酰胆碱受体和/或治疗各种疾病、疾病和症状的方法。所提供的化合物可以影响神经系统、精神病学和/或炎症系统等方面。
• Esters of thienobenzopyrans and thiopyranobenzopyrans
  申请人：Sharps Associates

  公开号：US03960871A1

  公开（公告）日：1976-06-01

  Novel thienobenzopyran and thiopyranobenzopyran esters represented by the formula ##SPC1## Wherein n is 0 to 3 and m is 0 to 3 and m + n = 2 or 3, R.sub.1 is lower alkyl, R.sub.2 is alkyl or cycloalkyl-lower alkyl, R.sub.4 is hydrogen or lower alkyl, R.sub.5 is hydrogen or lower alkyl, and R.sub.3 is ##EQU1## wherein Y is a straight or branched chain C.sub.1 to C.sub.8 alkylene, R.sub.6 is hydrogen or a lower alkyl, a is an integer from 1 to 4, b is an integer from 1 to 4, X is CH.sub.2, O, S or NR.sub.7 wherein R.sub.7 is hydrogen or lower alkyl, with the limitation that when X is O, S or NR.sub.7, a and b each must be 2; and the acid addition salts thereof.

  新颖的噻吲并苯并吡喃酯和噻吲并苯并吡喃酯的化学式为##SPC1## 其中n为0至3，m为0至3，且m + n = 2或3，R.sub.1为较低的烷基，R.sub.2为烷基或环烷基-较低的烷基，R.sub.4为氢或较低的烷基，R.sub.5为氢或较低的烷基，R.sub.3为##EQU1## 其中Y为直链或支链C.sub.1至C.sub.8的烷基，R.sub.6为氢或较低的烷基，a为1至4的整数，b为1至4的整数，X为CH.sub.2、O、S或NR.sub.7，其中R.sub.7为氢或较低的烷基，限制条件是当X为O、S或NR.sub.7时，a和b必须分别为2；及其酸盐。
• Anesthesia methods using benzopyrans and esters thereof as
  申请人：Abbott Laboratories

  公开号：US04025630A1

  公开（公告）日：1977-05-24

  Improved anesthesia methods comprising pretreating a patient to be anesthetized with a benzopyran of formula I ##STR1## wherein, in the C ring, X is NR.sub.1, S, CH.sub.2 or ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, loweralkanoyl, cycloalkyloweralkyl, cycloalkylloweralkanoyl, cycloalkyl, haloloweralkyl, haloloweralkenyl, phenylloweralkyl, phenyloweralkenyl or phenyloweralkylnyl; m is an integer from 0 to 3, n is an integer from 0 to 3 and n + m = 2 or 3; or the C ring is quinuclidine ring ##STR3## R.sub.2 is loweralkyl; R.sub.3 is hydrogen or ##STR4## wherein Y is a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.6, R.sub.6 being hydrogen or loweralkyl, with the limitation that when Z is O, S or NR.sub.5, the sum of a and b is 3 or 4, and R.sub.5 is hydrogen or loweralkyl; R.sub.4 is C.sub.1 -C.sub.20 straight or branched chain alkyl, cycloalkyl, or ##STR5## wherein Y is a straight or branched chain alkylene group having from one to ten carbon atoms, and each R.sub.7, R.sub.8 and R.sub.9 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof, with the limitation that when X is ##STR6## m = 2 and n = 2, R.sub.3 cannot be hydrogen.

  改进的麻醉方法包括使用化学式I的苯并吡喃预处理待麻醉的患者 其中，在C环中，X是NR.sub.1，S，CH.sub.2或##STR2## R.sub.1是氢，低烷基，低烯基，低炔基，低酰基，环烷基低烷基，环烷基低酰基，环烷基，卤代低烷基，卤代低烯基，苯基低烷基，苯基低烯基或苯基低烷基; m是0到3的整数，n是0到3的整数，n + m = 2或3;或C环是喹啉环##STR3## R.sub.2是低烷基; R.sub.3是氢或##STR4##其中Y是具有1至8个碳原子的直链或支链烷基基团，a是1到4的整数，b是1到4的整数，Z是CH.sub.2，O，S或NR.sub.6，R.sub.6为氢或低烷基，限制是当Z为O，S或NR.sub.5时，a和b的总和为3或4，R.sub.5为氢或低烷基; R.sub.4是C.sub.1-C.sub.20直链或支链烷基，环烷基，或##STR5##其中Y是具有1到10个碳原子的直链或支链烷基基团，每个R.sub.7，R.sub.8和R.sub.9是氢，卤素，三氟甲基或低烷基的相同或不同成员;及其药用盐，限制是当X为##STR6##时，m = 2，n = 2，R.sub.3不能是氢。
• Heterocyclic esters of benzopyranopyridines
  申请人：Sharps Associates

  公开号：US03991194A1

  公开（公告）日：1976-11-09

  Novel heterocyclic esters of benzopyranopyridines represented by the formula ##SPC1## Wherein R.sub.1 is hydrogen, lower alkyl, lower alkanoyl, cycloalkyl-lower alkyl, cycloalkyl-lower alkanoyl, lower alkenyl, lower alkynyl, halo-loweralkenyl, phenyl-lower alkyl, phenyl-lower alkenyl or phenyl-lower alkynyl; R.sub.2 is lower alkyl; R.sub.3 is an alkyl having one to twenty carbon atoms or a cycloalkyl-lower alkyl, Y is a straight or branched chain alkylene having one to eight carbon atoms, and R.sub.4 is a group of the formula ##EQU1## a is an integer from 1 to 4, b is an integer from 1 to 4 and X is CH.sub.2, O, S or N--R.sub.5 with R.sub.5 being hydrogen or lower alkyl, with the limitation that when X is O, S or N--R.sub.5, a and b each must be 2 and R.sub.6 is hydrogen or a lower alkyl group bonded to a carbon in the ring; and the acid addition salts thereof.

  该文献描述的是苯并吡啶酮的新异环酯类化合物，其化学式为##SPC1##其中，R.sub.1为氢、低碳基、低脂肪酰基、环烷基-低碳基、环烷基-低脂肪酰基、低烯基、低炔基、卤代-低烯基、苯基-低碳基、苯基-低烯基或苯基-低炔基；R.sub.2为低碳基；R.sub.3为具有1-20个碳原子的烷基或环烷基-低碳基；Y为直链或支链烷基，具有1-8个碳原子；R.sub.4为式子##EQU1##其中，a为1-4的整数，b为1-4的整数，X为CH.sub.2、O、S或N--R.sub.5，其中R.sub.5为氢或低碳基；但当X为O、S或N--R.sub.5时，a和b必须各为2，R.sub.6为氢或与环中碳原子成键的低碳基；以及它们的酸加成盐。
• Novel heterocyclic esters of benzopyranopyridines
  申请人：Sharps Associates

  公开号：US04042694A1

  公开（公告）日：1977-08-16

  Novel heterocyclic esters of benzopyranopyridines represented by the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, lower alkanoyl, cycloalkyl-lower alkyl, cycloalkyl-lower alkanoyl, lower alkenyl, lower alkynyl, halo-loweralkenyl, phenyl-lower alkyl, phenyl-lower alkenyl or phenyl-lower alkynyl; R.sub.2 is lower alkyl; R.sub.3 is an alkyl having one to twenty carbon atoms or a cycloalkyl-lower alkyl, Y is a straight or branched chain alkylene having one to eight carbon atoms, and R.sub.4 is a group of the formula ##STR2## a is an integer from 1 to 4, b is an integer from 1 to 4 and X is CH.sub.2, O, S or N--R.sub.5 with R.sub.5 being hydrogen or lower alkyl, with the limitation that when X is O, S or N--R.sub.5, a and b each must be 2 and R.sub.6 is hydrogen or a lower alkyl group bonded to a carbon in the ring; and the acid addition salts thereof.

  这是一个关于苯并吡啶酮的新型杂环酯的化学式，其表示为## STR1 ##其中R.sub.1为氢，低烷基，低酰基，环烷基-低烷基，环烷基-低酰基，低烯基，低炔基，卤代-低烯基，苯基-低烷基，苯基-低烯基或苯基-低炔基；R.sub.2为低烷基；R.sub.3为具有一到二十个碳原子的烷基或环烷基-低烷基；Y为具有一到八个碳原子的直链或支链烷基；R.sub.4为## STR2 ##其中a为1到4的整数，b为1到4的整数，X为CH.sub.2，O，S或N--R.sub.5，其中R.sub.5为氢或低烷基，但当X为O，S或N--R.sub.5时，a和b必须各为2，R.sub.6为氢或连接到环中碳原子的低烷基基团；以及它们的酸加合物盐。