Diethylene glycol glycolate | 68840-14-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Diethylene glycol glycolate
• 英文别名: 2-(2-hydroxyethoxy)ethyl 2-hydroxyacetate
• CAS: 68840-14-2
• 化学式: C₆H₁₂O₅
• 分子量: 164.16
• InChiKey: NLHSBHQNKMSMAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Reactive Distillation of a Carboxylic Acid and a Glycol
  申请人：Terrill Daniel Latham

  公开号：US20130310598A1

  公开（公告）日：2013-11-21

  Disclosed is a process for producing glycolate ester oligomers. The process comprises reacting ethylene glycol and glycolic acid to produce a stream of glycolate ester oligomers and glycolic acid oligomers while simultaneously removing water. The stream of glycolate ester oligomers and glycolic acid oligomers has a low concentration of water and glycolic acid-ends, and thus is useful in a subsequent hydrogenation reaction to produce ethylene glycol.

  本发明公开了一种生产乙二醇酸酯寡聚体的方法。该方法包括反应乙二醇和乙醇酸以产生一流的乙二醇酸酯寡聚体和乙醇酸寡聚体，同时去除水。该流的乙二醇酸酯寡聚体和乙醇酸寡聚体具有低水和乙醇酸端基浓度，因此在随后的氢化反应中用于生产乙二醇。
• Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
  申请人：The President and Fellows of Harvard College

  公开号：US20020192773A1

  公开（公告）日：2002-12-19

  The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a PKS or NRPS multidomain system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.

  本研究公开了从线性合成硫酯前体制备大环分子的方法。从 PKS 或 NRPS 多域系统中分离出来的切除硫酯酶结构域可催化环化反应。本发明还描述了可通过本发明方法高效环化的硫酯底物。此外，还介绍了通过本发明的大环化方法制备的大环分子，包括大内酯和大内酰胺。
• Methods for preparation of macrocyclic molecules macrocyclic molecules prepared thereby and substrates and solid supports for use therein
  申请人：President and Fellows of Harvard College

  公开号：US20030158377A1

  公开（公告）日：2003-08-21

  The invention features a new solid supports having at least one amino functionality and a linker bound to the solid support through at least a portion of the amino functional groups. The invention also features solid support bound substrates suitable for use in the formation of macrocycles by a TE domain catalyzed macrocyclization reaction. The invention features methods of making the solid supports and solid support bound substrates of the invention and methods of effecting macrocyclizations of solid support bound substrates. The invention further provides new macrocyclic molecules having one or more peptide domains and one or more polyketide domains in the macrocyclic ring. In another embodiment of the invention, libraries of macrocycles are provided as well as methods of forming libraries of macrocycles from libraries of solid support bound substrates are provided.

  本发明的特点是一种新的固体支持物，具有至少一个氨基官能团和一个通过至少部分氨基官能团与固体支持物结合的连接体。本发明还具有适用于通过 TE 结构域催化的大环化反应形成大环的固体支持物结合底物。本发明的特点是制造本发明的固体支持物和固体支持物结合底物的方法，以及对固体支持物结合底物进行大环化的方法。本发明进一步提供了在大环中具有一个或多个肽结构域和一个或多个聚酮结构域的新大环分子。在本发明的另一个实施方案中，提供了大环化合物库以及从固体支持物结合底物库中形成大环化合物库的方法。
• CHAIN EXTENDERS
  申请人：Gunatillake Pathiraja Arachchillage

  公开号：US20110287102A1

  公开（公告）日：2011-11-24

  The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula.(I)
• US4087470A
  申请人：——

  公开号：US4087470A

  公开（公告）日：1978-05-02