[1-甲基-2,4,6-三氧代-5-(1-苯基乙基)-1,3-二嗪农-5-基]丙酸酯 | 37431-42-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: [1-甲基-2,4,6-三氧代-5-(1-苯基乙基)-1,3-二嗪农-5-基]丙酸酯
• 英文名称: 1-Methyl-5-propionoxy-5-(1-phenyl-ethyl)-barbitursaeure
• 英文别名: 1-methyl-5-(1-phenyl-ethyl)-5-propionyloxy-pyrimidine-2,4,6-trione；1-Methyl-5-propionoxy-5-(1-phenylethyl)barbituric acid；[1-methyl-2,4,6-trioxo-5-(1-phenylethyl)-1,3-diazinan-5-yl] propanoate
• CAS: 37431-42-8
• 化学式: C₁₆H₁₈N₂O₅
• 分子量: 318.329
• InChiKey: DRYNBDDKJPGBDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  92.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933540000

文献信息

• Non-sedating barbituric acid derivatives
  申请人：Taro Pharmaceutical Industries Ltd.

  公开号：US20030187005A1

  公开（公告）日：2003-10-02

  The present invention relates to novel non-sedating barbituric acid derivatives, pharmaceutical compositions containing them and methods of neuroprotection in cases of cerebral ischemia, head trauma and other acute neurologic injuries, and prevention of resulting neuronal damage. The invention also relates to the use of non-sedating barbituric acid derivatives given in a manner and dosage effective to produce blood levels and brain levels of these drugs and/or their active metabolites sufficient to provide a therapeutic effect.

  本发明涉及新型非镇静型巴比妥酸衍生物、含有这些衍生物的药物组合物以及在脑缺血、头部创伤和其他急性神经损伤情况下的神经保护和预防由此导致的神经元损伤的方法。本发明还涉及非镇静型巴比妥酸衍生物的使用，其给药方式和剂量能有效地使这些药物和/或其活性代谢物的血药浓度和脑药浓度达到足以提供治疗效果的水平。
• Method of improving bioavailability for non-sedating barbiturates
  申请人：Yacobi Avraham

  公开号：US20080132529A1

  公开（公告）日：2008-06-05

  Administration of 1,3-dimethoxymethyl-5,5-diphenylbarbituric acid and its related compounds with food increases the bioavailability of these compounds. The ratios (fasting/fed) for geometric mean AUC 0-t were 35.6% (DMMDPB), 36.6% (MMMDPB) and 65.3% (DPB) and the geometric mean C max were 14.6% (DMMDPB), 31.9% (MMMDPB) and 62.9% (DPB). The cyclic ureides may be administered to a subject before or after ingestion of food within a defined time period.
• US6939873B2
  申请人：——

  公开号：US6939873B2

  公开（公告）日：2005-09-06