N-[(2-hydroxy-2-phenylethyl)]-N-[2-(2'-bromo-3', 4'-dimethoxyphenyl)ethyl]amine | 71157-80-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(2-hydroxy-2-phenylethyl)]-N-[2-(2'-bromo-3', 4'-dimethoxyphenyl)ethyl]amine
• 英文别名: 2-[2-(2-Bromo-3,4-dimethoxyphenyl)ethylamino]-1-phenylethanol
• CAS: 71157-80-7
• 化学式: C₁₈H₂₂BrNO₃
• 分子量: 380.282
• InChiKey: VCUOPTSUUKGZQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氧化苯乙烯 、 2-苯乙胺 以 丙酮 、 Petroleum ether 为溶剂， 生成 N-[(2-hydroxy-2-phenylethyl)]-N-[2-(2'-bromo-3', 4'-dimethoxyphenyl)ethyl]amine
  参考文献：
  名称：

  Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

  摘要：

  一组6,9-二取代-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶具有多巴胺活性。该发明的主要物种示例是6,9-二氯-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶和6,9-二氯-7,8-二羟基-1-(对羟基苯基)-2,3,4,5-四氢-1H-3-苯并哌啶的酸盐形式。

  公开号：

  US04171359A1

文献信息

• Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
  申请人：SmithKline Corporation

  公开号：US04171359A1

  公开（公告）日：1979-10-16

  A group of 6,9-disubstituted-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepi nes have dopaminergic activity. Examples of leading species of the invention are 6,9-dichloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6,9-dichloro-7,8-dihydroxy-1-(p-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H- 3-benzazepine in the form of an acid addition salt.

  一组6,9-二取代-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶具有多巴胺活性。该发明的主要物种示例是6,9-二氯-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶和6,9-二氯-7,8-二羟基-1-(对羟基苯基)-2,3,4,5-四氢-1H-3-苯并哌啶的酸盐形式。
• 6-Carboxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds and use
  申请人：SmithKline Corporation

  公开号：US04165372A1

  公开（公告）日：1979-08-21

  A group of 1-phenyl-3-benzazepines with structures characterized by having a carboxy derived substituent at position 6 which are dopaminergic agents or are intermediates for preparing other dopaminergic agents. Particular illustrative species include 6-carbomethoxy-7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-ben zazepine, 6-carboxy-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6-carbomethoxy-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3- benzazepine.

  一组1-苯基-3-苯并噁唑啉类化合物，其结构特征是在6位具有一个羧基取代基，这些化合物是多巴胺能药物或用于制备其他多巴胺能药物的中间体。具体说明的物种包括6-羧甲氧基-7,8-二羟基-3-甲基-1-苯基-2,3,4,5-四氢-1H-3-苯并噁唑啉、6-羧基-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并噁唑啉和6-羧甲氧基-7,8-二羟基-1-(4'-羟基苯基)-2,3,4,5-四氢-1H-3-苯并噁唑啉。
• Pharmacologically active 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, method of preparing them and intermediates
  申请人：SMITHKLINE BECKMAN CORPORATION

  公开号：EP0002327A1

  公开（公告）日：1979-06-13

  6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-IH-3-benzazepines of formula: in which: R is a lower alkyl of 1-6 carbons; R, is hydrogen, benzyl, phenethyl, lower alkanoyl of 1-5 carbons, lower alkyl of 1-5 carbons, lower alkyenyl of 3-5 carbons, furyl methyl, thienylmethyl or phenacyl; R2 and R3 are each hydrogen, lower alkyl of 1-5 carbons, lower alkanoyl of 2-5 carbons, benzyl or, when taken together, methylene; and R4 is hydrogen or one or two substituents from the group comprising trifluoromethyl, halo, methyl, methoxy, acetoxy, hydroxy or methylthio; or pharmaceutically acceptable, acid addition salts thereof show dopaminergic activity. Intermediates and chemical methods for preparing them are described. An important species is 6-methyl-7,8-dihydroxy-l(p-hydroxyphenyl) -2,3,4,5- tetrahydro -1N-3- benzazepine, as the base or one of its salts, which has antihypertensive activity.

  式中的 6-低级烷基-7,8-二羟基-1-苯基-2,3,4,5-四氢-IH-3-苯并氮杂卓： 其中 R是1-6个碳原子的低级烷基； R，是氢、苄基、苯乙基、1-5 个碳原子的低级烷酰基、1-5 个碳原子的低级烷基、3-5 个碳原子的低级烯基、呋喃甲基、噻吩甲基或苯乙基； R2 和 R3 分别是氢、1-5 个碳原子的低级烷基、2-5 个碳原子的低级烷酰基、苄基或合起来是亚甲基；以及 R4 是氢或来自三氟甲基、卤代、甲基、甲氧基、乙酰氧基、羟基或甲硫基等组的一个或两个取代基；或其药学上可接受的酸加成盐 显示多巴胺能活性。 本文介绍了中间体和制备它们的化学方法。其中一种重要的中间体是 6-甲基-7,8-二羟基-l（对羟基苯基）-2,3,4,5-四氢-1N-3-苯并氮杂卓，它的碱或盐具有抗高血压活性。
• Substituted benzazepines, processes for preparing them and pharmaceutical compositions containing them
  申请人：SMITHKLINE BECKMAN CORPORATION

  公开号：EP0004794A2

  公开（公告）日：1979-10-17

  A group of 6,9-disubstituted-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine have dopaminergic activity. Examples of compounds of the invention are 9-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-6-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6,9-dichioro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3- benzazepine, preferably in the form of an acid addition salt thereof, have antihypertensive activity.

  一组 6,9-二取代-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓具有多巴胺能活性。 本发明化合物的例子有 9-氯-7,8-二羟基-1-(对羟基苯基)-6-甲基-2,3,4,5-四氢-1H-3-苯并氮杂卓和 6,9-二硫代-7,8-二羟基-1-(对羟基苯基)-2,3,4,5-四氢-1H-3-苯并氮杂卓，最好是其酸加成盐的形式，具有抗高血压活性。
• 7,8-Substituted-1-phenyl-2,3,4,5-tetrahydro-1-H-3-benzazepines
  申请人：SMITHKLINE BECKMAN CORPORATION

  公开号：EP0026505A1

  公开（公告）日：1981-04-08

  A new series of 7,8-disubstituted-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines of use as intermediates in preparing compounds having dopaminergic activity which are described and claimed in European Patent Application 78300633.1.

  欧洲专利申请 78300633.1 中描述并声称了一系列新的 7,8-二取代-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓，可用作制备具有多巴胺能活性的化合物的中间体。