申请人:Northeastern University
公开号:US11219387B2
公开(公告)日:2022-01-11
Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.
本文提供了一些装置(例如,用于检测与某些疾病或病症相关的挥发性有机化合物和/或诊断某些疾病或病症的电化学传感器)。这些装置包括硅层上的一层或多层金属,以及与一层或多层金属电通信的分子印迹聚合物层,其中一层或多层金属分别独立选自铬、铂、金、镍、钴、钨、铑、铱、银、锡、钛或钽或其合金层。此外,还提供了使用这些装置的方法(例如,检测样品中的一种或多种分析物,检测和/或诊断受试者的疾病或状况),以及制造这些装置的方法。