O-valeroylcarnitine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: O-valeroylcarnitine
• 英文别名: 3-pentanoyloxy-4-(trimethylazaniumyl)butanoate
• 化学式: C12H23NO4
• 分子量: 245.32
• InChiKey: VSNFQQXVMPSASB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] DIAGNOSTIC METHODS, THERAPEUTIC AGENTS AND USES THEREOF<br/>[FR] PROCÉDÉS DE DIAGNOSTIC, AGENT THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：METABOLON INC

  公开号：WO2018022866A1

  公开（公告）日：2018-02-01

  The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.

  本发明提供了化合物(I)或其盐，并将其用作生物标志物来评估或监测受试者的肾功能，确定发展肾功能减退的易感性，根据肾功能水平对受试者进行分类，诊断或监测慢性肾病。还描述了化合物(I)的组成和制备方法。
• [EN] L-CARNITINE AND ALKANOYL L-CARNITINE PHYTATES AND PROCESS FOR PREPARING THE SAME<br/>[FR] PHYTATES DE L-CARNITINE ET D'ALCANOYLE L-CARNITINE, ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：SCIAN LAB LLC

  公开号：WO2010005465A1

  公开（公告）日：2010-01-14

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1 :1 to 6:1, wherein: n = 1-6; R1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和烷酰基L-肉碱盐与一般公式(I)的植酸，以及制备这些化合物的过程，其中L-肉碱或其烷酰衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n = 1-6；R1为植酸阴离子；R为氢、具有2-12个碳原子的直链烷酰基团或具有2-12个碳原子的支链烷酰基团。
• L-carnitine and alkanoyl L-carnitine phytates and process for preparing the same
  申请人：Chen Jian

  公开号：US20100317890A1

  公开（公告）日：2010-12-16

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1:1 to 6:1, wherein: n=1-6; R 1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和辛酰基L-肉碱盐与通式(I)的植酸，以及其制备方法，其中L-肉碱或其辛酰基衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n=1-6；R1是植酸阴离子；R是氢，具有2-12个碳原子的直链辛酰基或具有2-12个碳原子的支链辛酰基。
• Pharmaceutical compositions containing L-carnitine or derivatives thereof in combination with resveratrol or derivatives thereof, for the prophylaxis and treatment of cardiovascular disorders, peripheral vascular diseases and peripheral diabetic neuropathy
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0773020A2

  公开（公告）日：1997-05-14

  The co-ordinated therapeutic use of L-carnitine, lower alkanoyl L-carnitines or the pharmacologically acceptable salts thereof with resveratrol, resveratrol derivatives or resveratrol-containing natural products is disclosed for producing a medicament for the prophylaxis and treatment of cardiovascular disorders, peripheral vascular diseases and peripheral diabetic neuropathy.

  本发明公开了左旋肉碱、低级烷酰基左旋肉碱或其药理上可接受的盐与白藜芦醇、白藜芦醇衍生物或含白藜芦醇的天然产品的协调治疗用途，用于生产预防和治疗心血管疾病、外周血管疾病和外周糖尿病神经病变的药物。
• COMPOSTIONS COMPRISING L-CARNITINE OR DERIVATIVES THEREOF AND ANTIOXIDANTS
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0797993A1

  公开（公告）日：1997-10-01

  Therapeutical use is described of L-carnitine, some alkanoyl L-carnitines and the pharmacologically acceptable salts thereof in combination with hydrophilic antioxidants or lipophilic antioxidants or derivatives thereof or natural products containing said substances for the prevention and treatment of deseases of the central nervous system such as parkinsonism, trauma, cerebral palsy, diabetic neuropathy; of the peripheral nervous system such as diabetic peripheral neuropathy and traumatic nerve damage; of the cardiovascular system such as stroke ischaemic-reperfuson damage and intermittent claudication; and immune system abnormalities in conditions of low oxygen tension.

  描述了左旋肉碱、某些烷酰基左旋肉碱及其药理学上可接受的盐类与亲水性抗氧化剂或亲脂性抗氧化剂或其衍生物或含有上述物质的天然产品结合在一起的治疗用途，用于预防和治疗中枢神经系统疾病，如帕金森氏症、创伤、脑瘫、糖尿病神经病变；周围神经系统疾病，如糖尿病周围神经病变和外伤性神经损伤；心血管系统疾病，如中风缺血再发性损伤和间歇性跛行；以及低氧紧张状态下的免疫系统异常。