3,7-Bis-dimethylamino-phenothiazine-10-carboxylic acid ethyl ester | 36923-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3,7-Bis-dimethylamino-phenothiazine-10-carboxylic acid ethyl ester
• 英文别名: Ethyl 3,7-bis(dimethylamino)phenothiazine-10-carboxylate
• CAS: 36923-12-3
• 化学式: C₁₉H₂₃N₃O₂S
• 分子量: 357.477
• InChiKey: OTJWEJLMLMQKKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  亚甲兰 在 sodium dithionate 、 sodium carbonate 、 三乙胺 作用下， 以 水 、 甲苯 为溶剂， 反应 26.0h， 生成 3,7-Bis-dimethylamino-phenothiazine-10-carboxylic acid ethyl ester
  参考文献：
  名称：

  深入了解羟基自由基介导的笼状亚甲基蓝的裂解：芬顿催化剂在抗疟杂药活化中的作用。

  摘要：

  据报道，具有10-N氨基甲酰基键的亚甲蓝是羟基自由基触发的可裂解配体。通过该平台探测，血蛋白被证明是比常用的无机Fe（II）盐更有效的Fenton催化剂。该配体的适用性是通过在患病组织中以升高的活性氧水平触发的能力证明的，其中疟疾寄生化的红细胞为体外模型。

  DOI：

  10.1039/d0cc05204c

文献信息

• Methylene blue as a far-red light-mediated photocleavable multifunctional ligand
  作者：Huy Minh Dao、Chang-Hee Whang、Vijay Kumar Shankar、Yan-Hong Wang、Ikhlas A. Khan、Larry A. Walker、Islam Husain、Shabana I. Khan、S. Narasimha Murthy、Seongbong Jo

  DOI：10.1039/c9cc08916k

  日期：——

  Methylene blue (MB) was discovered as a multifunctional far-red photocleavable ligand capable of rendering a series of MB conjugated compounds with off-to-on fluorescence switch, photodynamic therapy and triggered release of conjugated molecule.

  亚甲蓝（MB）被发现为一种多功能的远红光可切割配体，能够使一系列与MB结合的化合物具有开关式荧光、光动力疗法和触发释放结合分子的能力。
• [EN] COSMETIC METHOD<br/>[FR] PROCÉDÉ COSMÉTIQUE
  申请人：OREAL

  公开号：WO2012023116A1

  公开（公告）日：2012-02-23

  The present invention provides a method for the cosmetic treatment of human keratinous material comprising the steps which consist in: a) applying at least one cosmetic composition comprising a photochromic compound, to the human keratinous material, said photochromic compound comprising : • a photocleavable function, in particular chosen from carbamate, carbonate or ester functions, and • a chromophore precursor covalently bonded to said photocleavable function, b) irradiating the treated area with light radiation, in particular radiation having a wavelength between 280 and 450 nm, so as to photocleave the photochromic compound and produce a compound of different color.
• Insight into hydroxyl radical-mediated cleavage of caged methylene blue: the role of Fenton's catalyst for antimalarial hybrid drug activation
  作者：Huy Minh Dao、Islam Husain、Vijay Kumar Shankar、Shabana I. Khan、S. Narasimha Murthy、Seongbong Jo

  DOI：10.1039/d0cc05204c

  日期：——

  ligand. Probed by this platform, hemoproteins were demonstrated to be a much more efficient Fenton's catalyst than commonly used inorganic Fe(II) salts. The applicability of this ligand was demonstrated through the capability of being triggered by elevated reactive oxygen species levels at diseased tissue, with malaria-parasitized erythrocytes as an in vitro model.

  据报道，具有10-N氨基甲酰基键的亚甲蓝是羟基自由基触发的可裂解配体。通过该平台探测，血蛋白被证明是比常用的无机Fe（II）盐更有效的Fenton催化剂。该配体的适用性是通过在患病组织中以升高的活性氧水平触发的能力证明的，其中疟疾寄生化的红细胞为体外模型。