N-(2-hydroxyethyl)ethanethioamide | 85112-98-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代酰胺
• 英文名称: N-(2-hydroxyethyl)ethanethioamide
• CAS: 85112-98-7
• 化学式: C₄H₉NOS
• 分子量: 119.188
• InChiKey: VEARWWYJZXJJSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-hydroxyethyl)ethanethioamide 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以30 mg的产率得到2-甲基-2-恶唑啉
  参考文献：
  名称：

  A Mild and Efficient Synthesis of 2-Oxazolines via Transamidation–Cyclodehydrosulfurisation­ of Thioamides with 2-Aminoethanol

  摘要：

  Transamidation of thioamides with 2-aminoethanol, followed by cyclodehydrosulfurisation of the resultant N-(beta-hydroxyethyl)thioamides, has been utilised for the mild and efficient synthesis of 2-oxazolines. The developed protocol was found to be of general applicability.

  DOI：

  10.1055/s-0032-1317341
• 作为产物：
  描述：

  C.I.酸性橙108 、 硫代乙酰胺 反应 0.25h， 生成 N-(2-hydroxyethyl)ethanethioamide
  参考文献：
  名称：

  A Mild and Efficient Synthesis of 2-Oxazolines via Transamidation–Cyclodehydrosulfurisation­ of Thioamides with 2-Aminoethanol

  摘要：

  Transamidation of thioamides with 2-aminoethanol, followed by cyclodehydrosulfurisation of the resultant N-(beta-hydroxyethyl)thioamides, has been utilised for the mild and efficient synthesis of 2-oxazolines. The developed protocol was found to be of general applicability.

  DOI：

  10.1055/s-0032-1317341

文献信息

• A Mild and Efficient Synthesis of 2-Oxazolines via Transamidation–Cyclodehydrosulfurisation­ of Thioamides with 2-Aminoethanol
  作者：Uma Pathak、D. Goud

  DOI：10.1055/s-0032-1317341

  日期：——

  Transamidation of thioamides with 2-aminoethanol, followed by cyclodehydrosulfurisation of the resultant N-(beta-hydroxyethyl)thioamides, has been utilised for the mild and efficient synthesis of 2-oxazolines. The developed protocol was found to be of general applicability.