N-tert.Butyl-N'-phenylhydrazin | 118655-95-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-tert.Butyl-N'-phenylhydrazin
• 英文别名: 1-(1,1-dimethylethyl)-2-phenylhydrazine；1-Tert-butyl-2-phenylhydrazine
• CAS: 118655-95-1
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: IXEIOGHIJOCKNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-tert.Butyl-N'-phenylhydrazin 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 0.75h， 生成 3,4-dihydro-1-phenyl-3-(1,1dimethylethyl)phthalazine
  参考文献：
  名称：

  Synthesis of .alpha.-substituted 1,2-benzenedimethanamines

  摘要：

  DOI：

  10.1021/jo00017a043
• 作为产物：
  描述：

  1-tert-Butyl-2-phenyldiazen 在 铂 氢气 作用下， 以 乙醇 为溶剂， 生成 N-tert.Butyl-N'-phenylhydrazin
  参考文献：
  名称：

  Structures of the 1:1:1 adducts of the nitroso-isonitrile-isocyanate reaction. Possible intermediacy of a carbodiimide N-oxide

  摘要：

  DOI：

  10.1021/jo00909a021

文献信息

• Storable gas generating compositions
  申请人：Saudi Arabian Oil Company

  公开号：US10590326B1

  公开（公告）日：2020-03-17

  The present application provides an aqueous fluid containing a gas-generating compound such as an azo compound, a hydrazide compound, or a semicarbazide compound. The aqueous fluid may also contain an amine compound, an oxidizer, or viscosifier, and a foaming surfactant. The aqueous composition may be storable at pH of less than about 5 without any appreciable gas generation, and may be activated to produce gas when mixed with a wellbore fluid for use in downhole applications.

  本申请提供了一种含气化合物（如偶氮化合物、酰肼化合物或半咔嗪化合物）的水基流体。该水性流体还可含有胺化合物、氧化剂或增粘剂以及发泡表面活性剂。水性组合物在 pH 值小于 5 时可储存，不会产生明显的气体，当与井筒流体混合用于井下应用时，可活化产生气体。
• Gas generating compositions
  申请人：Saudi Arabian Oil Company

  公开号：US10858565B2

  公开（公告）日：2020-12-08

  The present application provides a gas-generating aqueous fluid containing a gas-generating compound like an azo compound, and an organic amine like a primary, secondary or tertiary amine, a hydrazine, a hydrazide, or a semicarbazide. The aqueous fluid may also a viscosifier, and a foaming surfactant. The present application also provides a method of using the gas-generating composition to modulate density of a wellbore fluid for use in downhole applications. The method optionally includes adding an oxidizer to the wellbore fluid.

  本申请提供了一种可产生气体的水性流体，其中含有偶氮化合物等可产生气体的化合物，以及伯胺、仲胺或叔胺、肼、肼酰胺或半肼等有机胺。水性流体还可以是增粘剂和发泡表面活性剂。本申请还提供了一种使用气体生成组合物调节井下应用中井筒流体密度的方法。该方法可选地包括向井筒流体中添加氧化剂。
• Anti-infective heterocyclic compounds and uses thereof
  申请人：Bioimics AB

  公开号：US11130741B2

  公开（公告）日：2021-09-28

  The present invention relates to heterocyclic compounds of Formula I useful as anti-infective agents. The present invention further relates to a method of treating an infection by administering such compounds, and to pharmaceutical compositions comprising such compounds.

  本发明涉及可用作抗感染剂的式Ⅰ杂环化合物。本发明还涉及通过施用此类化合物治疗感染的方法，以及包含此类化合物的药物组合物。
• Design, Synthesis, and Pharmacological Activity of Nonallergenic Pyrazolone-Type Antipyretic Analgesics
  作者：Naoto Uramaru、Hidenari Shigematsu、Akihisa Toda、Reiko Eyanagi、Shigeyuki Kitamura、Shigeru Ohta

  DOI：10.1021/jm101208x

  日期：2010.12.23

  To develop novel nonallergenic pyrazolone analgesics, we synthesized a series of compounds in which position 1 of the pyrazolone ring was substituted in place of the original methyl group in order to block the formation of allergenic metabolites via N-dealkylation. These pyrazolone analogues were found to show as potent an antipyretic and analgesic effect as antipyrine (AT). In an examination of allergenicity, AT induced a typical skin reaction in guinea pigs, whereas the pyrazolone analogues were inactive. When AT was administered (po) to rats, norantipyrine (NORA) as an active metabolite was detected in the urine, whereas similar administration of the pyrazolone analogues did not afford NORA. We conclude that these novel pyrazolone analogues were nonallergenic because they were not converted to allergenic metabolites in vivo. Because these compounds retain the antipyretic and analgesic activities of AT, they are considered to be promising candidates for nonallergenic antipyretic analgesics.
• SQUARAINE DYES
  申请人：Amersham Pharmacia Biotech UK Limited

  公开号：EP1165693A2

  公开（公告）日：2002-01-02