(R)-3-(3-Tetradecylureido)-4-(trimethylammonio)butanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-3-(3-Tetradecylureido)-4-(trimethylammonio)butanoate
• 英文别名: 3-(tetradecylcarbamoylamino)-4-(trimethylazaniumyl)butanoate
• 化学式: C22H45N3O3
• 分子量: 399.6
• InChiKey: BMZYTDRMCBZVNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  81.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMBINATION OF ANTIDIABETIC DRUGS
  申请人：SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP1592417A1

  公开（公告）日：2005-11-09
• Combination of antidiabetic drugs
  申请人：Giannessi Fabio

  公开号：US20060058385A1

  公开（公告）日：2006-03-16

  The combination of R-4-trimethylammonio-3-(tetra-decylcarbamoyl)-aminobutyrate and metformin is disclosed. Said combination of anti-diabetic drugs exerts a synergic action and allows the administration of the two drugs at doses such as to avoid or reduce the occurrence of side effects. The combination is also useful for improving the therapeutic cover far from mealtimes, and in postabsorption and fasting conditions.
• MULTI-FUNCTIONAL NANOPARTICLES FOR VACCINATION
  申请人：Zhang Yuan

  公开号：US20190307703A1

  公开（公告）日：2019-10-10

  The present invention generally relates to a dynamic nanoparticle used for vaccination. Specifically, the claimed product comprises of an adaptive nanoparticle wherein both the outer surface and the inner core are customizable for targeted application.
• METHOD FOR ENHANCED NUCLEIC ACID TRANSFECTION USING A PEPTIDE
  申请人：Zhang Yuan

  公开号：US20190307901A1

  公开（公告）日：2019-10-10

  A method for genetic transfection of mammalian cells is disclosed using a novel nanoparticle. The method comprises of mixing cationic peptides to nucleic acids, and then subsequently incorporating this mixture into a liposome with surface modification for transfection purposes and other medical application. With various types of cationic peptides envisioned, the method can be used for developing a nanoparticle comprising of either anionic or cationic liposomes, and for incorporating any type of nucleic acid. The medical application of this technology includes, but not limited to, gene therapy and nucleic acid based vaccination against a broad range of diseases, such as cancer and infectious disease.
• [EN] COMBINATION OF ANTIDIABETIC DRUGS<br/>[FR] COMBINAISON DE MEDICAMENTS ANTIDIABETIQUES
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2004069239A1

  公开（公告）日：2004-08-19

  The combination of R-4-trimethylammonio-3-(tetra-decylcarbamoyl)-aminobutyrate and metformin is disclosed. Said combination of anti-diabetic drugs exerts a synergic action and allows the administration of the two drugs at doses such as to avoid or reduce the occurrence of side effects. The combination is also useful for improving the therapeutic cover far from mealtimes, and in postabsorption and fasting conditions.