(Z)-1-oxo-1-[3-(trimethylazaniumyl)propoxy]but-2-en-2-olate;hydrochloride

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-1-oxo-1-[3-(trimethylazaniumyl)propoxy]but-2-en-2-olate;hydrochloride
• 化学式: C10H20ClNO3
• 分子量: 237.72
• InChiKey: RDENMEANRYNVPC-UYTGOYFPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.91
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] MACROMOLECULAR PRODRUGS FOR HARD TISSUE AND METHODS OF USE THEREOF<br/>[FR] PROMÉDICAMENTS MACROMOLÉCULAIRES POUR TISSU DUR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：NEW YORK SOC RUPTURED & CRIPPLED MAINTAINING HOSPITAL FOR SPECIAL SURGERY

  公开号：WO2014036548A1

  公开（公告）日：2014-03-06

  Compositions for intravenous administration and methods for treating bone diseases, disorders, and fractures comprising macromolecular prodrugs of hydrophobic bone anabolic agents are provided. Specifically, novel macromolecular amphiphilic prodrugs wherein at least three molecules of simvastatin are conjugated to polyethylene glycol, which spontaneously form micelles in aqueous solutions are provided.

  提供用于静脉给药的组成物以及包括疏水性骨骼合成剂的巨分子前药治疗骨骼疾病、紊乱和骨折的方法。具体而言，提供新颖的巨分子两亲性前药，其中至少三分子辛伐他汀与聚乙二醇共轭，它们在水溶液中自发形成胶束。
• COSMETIC PROCESS FOR MAKING-UP AND/OR CARING FOR THE SKIN AND/OR THE LIPS
  申请人：L'OREAL

  公开号：US20150290116A1

  公开（公告）日：2015-10-15

  A cosmetic process for making-up and/or caring for skin and/or lips, includes the application to skin and/or lips of a cosmetic composition including, in a physiologically acceptable medium, at least one supramolecular polymer and at least one hydrophobic film-forming polymer. Particular compositions may be used in the process.

  一种化妆和/或护理皮肤和/或嘴唇的化妆过程，包括将至少一种超分子聚合物和至少一种疏水膜形成聚合物混合于生理可接受的介质中的化妆组合物涂抹到皮肤和/或嘴唇上。特定的组合物可用于该过程。
• RADICAL POLYMERIZATION INITIATOR AND METHOD FOR PRODUCING POLYMERS
  申请人：ZEON CORPORATION

  公开号：US20160297755A1

  公开（公告）日：2016-10-13

  The present invention involves a radical polymerization initiator comprising an organotellurium compound represented by a formula (1), wherein R 1 represents an alkyl group or the like, each of R 2 and R 3 independently represents a hydrogen atom or the like, and each of R 4 , R 5 , and R 6 independently represents a hydrogen atom or the like. The present invention provides: a radical polymerization initiator that is useful for producing a polymer that includes a double bond at the molecular terminal; and a method for producing a polymer that utilizes the radical polymerization initiator.

  本发明涉及一种自由基聚合引发剂，其包括由式（1）代表的有机碲化合物，其中R1代表烷基基团或类似物，R2和R3各自独立地代表氢原子或类似物，R4、R5和R6各自独立地代表氢原子或类似物。本发明提供了一种有用于生产在分子末端包含双键的聚合物的自由基聚合引发剂，以及利用该自由基聚合引发剂生产聚合物的方法。
• Organic articles
  申请人：——

  公开号：US20020197414A1

  公开（公告）日：2002-12-26

  The invention relates to novel composite materials comprising (a) an inorganic or organic bulk material having covalently bound to its surface initiator moieties for radical polymerization; and (b) a hydrophilic surface coating obtainable by applying one or more different ethylenically unsaturated hydrophilic macromonomers of formula (1) as outlined in the claims to the bulk material surface provided with the initiator radicals and polymerizing said macromonomers. The composite materials of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

  该发明涉及一种新型复合材料，包括(a)具有共价键结合到其表面引发剂基团用于自由基聚合的无机或有机块材料；和(b)通过将公式(1)中所述的一种或多种不同的乙烯不饱和亲水性大分子单体应用于具有引发剂基团的块材料表面以及聚合所述大分子单体而获得的亲水性表面涂层。该发明的复合材料具有良好的特性，包括对基底的附着性、耐久性、亲水性、润湿性、生物相容性和渗透性，因此适用于制造生物医学器件，如眼科设备。
• CROSSLINKING AGENT, CROSSLINKED POLYMER, AND USES THEREOF
  申请人：Tanaka Shinichi

  公开号：US20100209723A1

  公开（公告）日：2010-08-19

  There is provided a novel crosslinking agent for use in crosslinked polymer fabrication, specifically a crosslinking agent containing at least one compound selected from glyoxylate and a glyoxylic acid ester derivative represented by the following general formula (1): wherein R 1 and R 2 each independently represents an alkyl group having 1 to 10 carbon atoms and R 3 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.

  提供了一种新型交联剂，用于交联聚合物的制备，具体来说，这种交联剂包含至少一种从乙酰乙酸酯和以下通用公式（1）表示的乙酰乙酸酯衍生物中选择的化合物：其中R1和R2各自独立表示具有1至10个碳原子的烷基基团，R3表示氢原子或具有1至10个碳原子的烷基基团。