(E)-7-[(1S,3S)-3-hydroxy-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-7-[(1S,3S)-3-hydroxy-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
• 化学式: C₂₂H₃₆O₅
• 分子量: 380.5
• InChiKey: QAOBBBBDJSWHMU-BKSAQPBESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• AMINO ACID SALTS OF PROSTAGLANDINS
  申请人：DeLong Mitchell A.

  公开号：US20100105775A1

  公开（公告）日：2010-04-29

  The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.

  本发明涉及新型氨基酸前列腺素盐及其制备和使用方法。
• Optimized CRISPR/cas9 systems and methods for gene editing in stem cells
  申请人：Editas Medicine, Inc.

  公开号：US11390884B2

  公开（公告）日：2022-07-19

  The methods and compositions described herein surprisingly increase CRISPR/Cas-mediated gene editing in stem cells by transiently treating the cells with a stem cell viability enhancer prior to and/or after contacting the cells with one or more CRISPR/Cas9 components. Further, this treatment also surprisingly results in increased engraftment of the stem cells into the target tissue of a subject. The present disclosure also provides one or more modified CRISPR/Cas9 components which, when used in combination with the stem cell viability enhancer, further increases the frequency of gene editing in stem cells, increases stem cell viability, and increases stem cell engraftment.

  本文所述的方法和组合物在干细胞与一种或多种CRISPR/Cas9成分接触之前和/或之后，用干细胞活力增强剂瞬时处理细胞，从而令人惊讶地增加了干细胞中CRISPR/Cas介导的基因编辑。此外，这种处理方法还令人惊奇地增加了干细胞在受试者靶组织中的移植。本公开还提供了一种或多种经修饰的CRISPR/Cas9成分，当与干细胞活力增强剂结合使用时，可进一步增加干细胞基因编辑的频率，提高干细胞活力，增加干细胞移植。
• Compositions and methods for immune cell modulation in adoptive immunotherapies
  申请人：Fate Therapeutics, Inc.

  公开号：US11413309B2

  公开（公告）日：2022-08-16

  Compounds that either produced a higher proportion or greater absolute number of phenotypically identified nave, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified. Compositions and methods for modulating immune cells including T, NK, and NKT cells for adoptive cell therapies with improved efficacy are provided.

  翻译如下： 发现了一些化合物，这些化合物能够产生更高比例或绝对数量的表型鉴定的naïve T细胞、干细胞记忆T细胞、中央记忆T细胞、适应性NK细胞和I型NKT细胞。此外，还提供了调节免疫细胞（包括T细胞、NK细胞和NKT细胞）的组合物和方法，用于提高过继细胞疗法的疗效。
• OPTIMIZED CRISPR/CAS9 SYSTEMS AND METHODS FOR GENE EDITING IN STEM CELLS
  申请人：Editas Medicine, Inc.

  公开号：EP3294896A1

  公开（公告）日：2018-03-21
• COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES
  申请人：Fate Therapeutics, Inc.

  公开号：US20190125795A1

  公开（公告）日：2019-05-02

  Compounds that either produced a higher proportion or greater absolute number of phenotypically identified nave, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified. Compositions and methods for modulating immune cells including T, NK, and NKT cells for adoptive cell therapies with improved efficacy are provided.