(E)-7-[3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-7-[3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid
• 化学式: C₂₃H₃₂O₅
• 分子量: 388.5
• InChiKey: YFHHIZGZVLHBQZ-FJWIYWAESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• NOVEL PROCESSES FOR THE PREPARATION OF PROSTAGLANDIN AMIDES
  申请人：Havasi Gábor

  公开号：US20140135503A1

  公开（公告）日：2014-05-15

  The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R 1 and R 2 independently represent hydrogen atom or a straight or branched C 1-10 alkyl- or aralkyl- group, optionally substituted with —ONO 2 group, or an aralkyl- or aryl- group, which contains heteroatom, R 3 represents a straight or branched, saturated or unsaturated C 4-6 hydrocarbon group, or a C 4-10 alkylcycloalkyl- or cycloalkyl- group, or an optionally with alkyl group or halogen atom substituted phenyl-, C 7-10 alkylaryl- or hetaryl- group, Y represents (CH 2 ), group or 0 atom or S atom, and where n=0-3.

  本发明涉及一种用于制备通式I的前列腺素酰胺的方法，其中在该式中，用虚线标记的键可以是单键或双键，在双键位于位置5、6和13、14时，它们可以是顺式或反式取向，Q代表一个羟基团，Z代表一个羟基或氧基团，R1和R2独立地表示氢原子或直链或支链C1-10烷基或芳基基团，可选地取代为—ONO2基团，或者一个含有杂原子的芳基基团，R3表示直链或支链、饱和或不饱和的C4-6碳氢基团，或者一个C4-10烷基环烷基或环烷基基团，或者一个可选地与烷基基团或卤原子取代的苯基、C7-10烷基芳基或杂芳基基团，Y代表(CH2)、基团或0原子或S原子，其中n=0-3。
• TROMETHAMINE SALT OF BIMATOPROST ACID IN CRYSTALLINE FORM 1, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF
  申请人：ALLERGAN, INC.

  公开号：US20150376125A1

  公开（公告）日：2015-12-31

  The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.

  本发明提供了晶体形式1和非晶态形式的（Z）-7- [3,5-二羟基-2-（（E）-3-羟基-5-苯基-戊-1-烯基）-环戊基] -庚-5-烯酸的曲美他明盐。该化合物也可以称为“贝马托普罗斯酸的曲美他明盐”。本发明的晶体形式适用于固体眼内植入物或局部制剂，用于治疗各种眼部疾病，例如眼压增高。
• [EN] TROMETHAMINE SALT OF BIMATOPROST ACID IN CRYSTALLINE FORM 1, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF<br/>[FR] SEL DE TROMÉTHAMINE DE BIMATOPROST ACIDE SOUS LA FORME CRISTALLINE 1, PROCÉDÉS DE PRÉPARATION ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：ALLERGAN INC

  公开号：WO2015199729A1

  公开（公告）日：2015-12-30

  The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as "tromethamine salt of bimatoprost acid." The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.

  本发明提供了晶体形式1和非晶态形式的(Z)-7-[3,5-二羟基-2-((E)-3-羟基-5-苯基-戊-1-烯基)-环戊基]-庚-5-烯酸的醇胺盐。该化合物也可以称为“贝马特普罗斯特酸的醇胺盐”。本发明的晶体形式可用于固体眼内植入物或局部制剂，用于治疗各种眼部疾病，例如眼压增高。
• Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
  申请人：ALLERGAN, INC.

  公开号：US10273206B2

  公开（公告）日：2019-04-30

  The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.

  本发明提供了(Z)-7-[3,5-二羟基-2-((E)-3-羟基-5-苯基-戊-1-烯基)-环戊基]-庚-5-烯酸的三甲胺盐，呈结晶形式1和无定形形式。该化合物也可称为 "双马前列腺素的曲美他胺盐"。本发明的结晶形式适用于固体眼部植入剂或外用制剂，用于治疗各种眼部疾病，例如眼压过高。
• [EN] NOVEL PROCESSES FOR THE PREPARATION OF PROSTAGLANDIN AMIDES<br/>[FR] NOUVEAU PROCÉDÉ POUR LA PRÉPARATION D'AMIDES DE PROSTAGLANDINES
  申请人：CHINOIN ZRT

  公开号：WO2012164324A9

  公开（公告）日：2014-01-09