N-(γ-L-glutamyl)putrescine | 58316-51-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(γ-L-glutamyl)putrescine
• 英文别名: gamma-L-Glutamylputrescine；(2S)-2-amino-5-(4-aminobutylamino)-5-oxopentanoic acid
• CAS: 58316-51-1
• 化学式: C₉H₁₉N₃O₃
• 分子量: 217.268
• InChiKey: WKGTVHGVLRCTCF-ZETCQYMHSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N4-(tert-butoxycarbonyl)-N1-(N-tert-butoxycarbonyl-O-tert-butyl-γ-L-glutamyl)putrescine 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以55%的产率得到N-(γ-L-glutamyl)putrescine
  参考文献：
  名称：

  N1-和N8-（γ-L-谷氨酰基）亚精胺和（γ-L-谷氨酰基）腐胺的合成

  摘要：

  由N-Boc保护的腐胺合成了细菌（如大肠杆菌和铜绿假单胞菌）的（γ-L-谷氨酰胺基）腐胺和N1-和N8-（γ-L-谷氨酰胺基）亚精胺，可能的区域异构产物。和1,3-丙二胺。

  DOI：

  10.2174/157017811794557813

文献信息

• Methods for ameliorating icthyosiform skin diseases
  申请人：——

  公开号：US20030072795A1

  公开（公告）日：2003-04-17

  The present invention relates to the discovery of a method to provide stabilized transglutaminase 1 enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin cells. Novel biological tools, prophylactics, therapeutics, cosmetics, and methods of use of the foregoing for study, prevention, and treatment of skin disorders are also disclosed.

  本发明涉及发现一种方法，以提供稳定的转谷氨酰胺酶1酶，包裹蛋白和其他必要分子以组装细胞外壳到皮肤细胞上。还公开了新的生物工具、预防药、治疗药、化妆品以及上述用于研究、预防和治疗皮肤疾病的使用方法。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• MUTANT MICROORGANISM WITH HIGH ABILITY OF PRODUCING PUTRESCINE AND PREPARATION OF PUTRESCINE USING SAME
  申请人：Korea Advanced Institute of Science and Technology

  公开号：EP2281880B1

  公开（公告）日：2016-07-06
• MUTANT MICROORGANISMS HAVING A HIGH ABILITY TO PRODUCE PUTRESCINE AND METHOD FOR PRODUCING PUTRESCINE USING THE SAME
  申请人：Lee Sang Yup

  公开号：US20100203599A1

  公开（公告）日：2010-08-12

  Provided are mutant microorganisms having the ability to produce a high concentration of putrescine wherein gene(s) involved in the putrescine degradation or utilization pathway is inactivated or deleted and a preparation method thereof. A method for producing putrescine in high yield by culturing the mutant microorganisms is also provided. The mutant microorganisms are useful for producing a high concentration of putrescine which can be widely used in various industrial applications.
• US8481293B2
  申请人：——

  公开号：US8481293B2

  公开（公告）日：2013-07-09