monosodium N-oleoylglutamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: monosodium N-oleoylglutamate
• 英文别名: sodium;(2S)-5-hydroxy-2-[[(Z)-octadec-9-enoyl]amino]-5-oxopentanoate
• 化学式: C23H40NNaO5
• 分子量: 433.6
• InChiKey: FGFAZPVAUUEKBP-LZUSKFISSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.13
• 重原子数：
  30
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PREPARATION METHOD AND USE OF N-ACYL ACIDIC AMINO ACID OR SALT THEREOF
  申请人：NANJING HUASHI CHEMICAL CO., LTD

  公开号：US20160200668A1

  公开（公告）日：2016-07-14

  The invention provides a preparation method of N-acyl acidic amino acid or a salt thereof, comprising subjecting a fatty acyl chloride and an amino acid to an amidation reaction under an alkaline condition. The preparation method is characterized in that in the amidation reaction, water is used as a solvent, an acidic amino acid or a salt thereof is used as a main raw material and a small amount of a neutral amino acid or a salt thereof is used as an auxiliary raw material, and the method comprises the following steps: under a stirring condition, firstly adding the fatty acyl chloride dropwise into an aqueous solution of the acidic amino acid or the salt thereof; adding an alkali to adjust the pH value of the reaction solution; after a certain amount of fatty acyl chloride having been added dropwise, adding an aqueous solution of the neutral amino acid or the salt thereof, and continuing to add the fatty acyl chloride dropwise until the addition is finished and stirring to maintain the reaction. The preparation method uses the reaction of the mixed amino acids and the fatty acyl chloride under a water-phase system, so that the conversion rates of the amino acids and the acyl chloride can be remarkably increased and the amount of residual amino acids is greatly reduced. The product can be directly used as a surfactant after simple post-treatment, and thus the cost is greatly reduced.

  本发明提供了一种N-酰基酸性氨基酸或其盐的制备方法，包括在碱性条件下使脂肪酰氯和氨基酸进行酰胺化反应。该制备方法的特点在于，在酰胺化反应中，水被用作溶剂，酸性氨基酸或其盐被用作主要原料，少量的中性氨基酸或其盐被用作辅助原料，该方法包括以下步骤：在搅拌条件下，首先滴加脂肪酰氯到酸性氨基酸或其盐的水溶液中；加入碱调节反应溶液的pH值；在滴加一定量的脂肪酰氯后，加入中性氨基酸或其盐的水溶液，并继续滴加脂肪酰氯直至加完为止，并搅拌以维持反应。该制备方法利用水相系统下混合氨基酸和脂肪酰氯的反应，使氨基酸和酰氯的转化率显著提高，残留氨基酸的量大大降低。产品可以经过简单的后处理直接用作表面活性剂，从而大大降低成本。
• POWDER SURFACE TREATMENT METHOD, SURFACE TREATING AGENT COMPOSITION USED THEREFOR, AND SURFACE-TREATED POWDER
  申请人：AJINOMOTO CO., INC.

  公开号：EP4029572A1

  公开（公告）日：2022-07-20

  The present invention provides a powder surface treatment method comprising (i) a step for mixing 0.001-20 parts by mass of a surface treating agent composition with 100 parts by mass of a power, and (ii) a step for adding an acidic liquid, followed by mixing, wherein the surface treating agent composition contains (a)-(d) below: (a) one or more selected from among an N-acyl amino acid having a carbon chain length of C8-C22 and a salt thereof; (b) one or more selected from among monohydric and polyhydric alcohols; (c) water; and (d) one or more selected from among (dl) an amino acid having an isoelectric point of 7.5-11, and (d2) a compound which generates an ion selected from among an aluminum ion, a magnesium ion, a calcium ion, a zinc ion, a zirconia ion, and a titanium ion, in the surface treating agent composition.

  本发明提供了一种粉末表面处理方法，包括(i)将0.001-20份(质量)表面处理剂组合物与100份(质量)动力混合的步骤，以及(ii)加入酸性液体，然后混合的步骤，其中表面处理剂组合物包含以下(a)-(d)：(a) 一种或多种选自碳链长度为 C8-C22 的 N-酰基氨基酸及其盐； (b) 一种或多种选自一元醇和多元醇； (c) 水；和 (d) 一种或多种选自等电点为 7.5-11，以及(d2)在表面处理剂组合物中产生选自铝离子、镁离子、钙离子、锌离子、氧化锆离子和钛离子中的一种或多种离子的化合物。
• COSMETIC COMPOSITION AND EMULSION COMPOSITION
  申请人：NOF CORPORATION

  公开号：EP0564656B1

  公开（公告）日：1999-02-03
• Fatty Acid Acylated Amino Acids for Growth Hormone Delivery
  申请人：Novo Nordisk Health Care AG

  公开号：US20150250882A1

  公开（公告）日：2015-09-10

  The present invention relates to growth hormone compositions comprising a fatty acid acylated amino acids (FA-aa's), which may be used in pharmaceutical compositions such as pharmaceutical compositions for oral administration of growth hormone.
• DRIP-FREE CLEANSING MASK WITH ENHANCED ACTIVE DEPOSITION
  申请人：L'OREAL

  公开号：US20210128419A1

  公开（公告）日：2021-05-06

  Cleansing mask composition are provided in the present disclosure. The cleansing mask compositions includes a) from about 0.4 to 9 wt. % of a first thickener chosen from non-acrylate base rheology modifier; b) from about 0.2 to about 2 wt. % of a second thickener chosen from acrylic- or acrylate based thickeners; c) from about 2 to 25 wt. % of at least one surfactant; d) a skin care active ingredient; and wherein the and is drip free once applied on the skin.