L-Lysine hexadecyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Lysine hexadecyl ester
• 英文别名: hexadecyl (2S)-2,6-diaminohexanoate
• 化学式: C₂₂H₄₆N₂O₂
• 分子量: 370.6
• InChiKey: SAFJPEUEQJHING-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  26
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  78.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Contrast agents
  申请人：——

  公开号：US20040146462A1

  公开（公告）日：2004-07-29

  Ultrasonic visualisation of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations comprise an injectable aqueous medium comprising dispersed gas and an injectable oil-in-water emulsion in which the oil phase comprises a diffusible component capable of diffusion in vivo into the dispersed gas to promote temporary growth thereof, such that material present at the surfaces of the dispersed gas phase and material present at the surfaces of the dispersed oil phase have affinity for each other, e.g. as a result of having opposite charges. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences between return signal intensity from normal and hypoperfused myocardial tissue respectively.

  使用新型含气对比剂制剂进行超声成像，特别是心肌和其他组织的灌注成像，这些制剂促进体内气相的可控、暂时性生长，因此可以作为沉积的灌注示踪剂。这些制剂包括可注射的水性介质，其中包含分散的气体和可注射的油水乳液，其中油相包含可扩散的成分，能够在体内扩散到分散的气体中促进其暂时性生长，使分散气体相和分散油相表面的物质互相吸引，例如由于具有相反的电荷。在心脏灌注成像中，这些制剂可以优势地与血管扩张药物（如腺苷）同时使用，以增强正常和低灌注心肌组织的回波信号强度差异。
• Lysine esters used as absorption enhancing agents
  申请人：Merck & Co., Inc.

  公开号：EP0162747A1

  公开（公告）日：1985-11-27

  Novel lysine esters used as absorption enhancing agents for gastrointestinally and rectally administered drugs. Also provided are processes for preparation of said lysine ester coupounds as well as pharmaceutical formulations and methods for their use as absorption enhancing agents.

  新型赖氨酸酯可用作胃肠道和直肠给药的促进吸收剂。此外，还提供了上述赖氨酸酯偶联物的制备工艺以及用作吸收促进剂的药物制剂和方法。
• IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS
  申请人：Marsden, John Christopher

  公开号：EP1073473A1

  公开（公告）日：2001-02-07
• CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION
  申请人：Monsanto Technology LLC

  公开号：EP1135398A1

  公开（公告）日：2001-09-26
• US4296095A
  申请人：——

  公开号：US4296095A

  公开（公告）日：1981-10-20