3-Amino-2-(3-nitrophenyl)propanoic acid | 1263282-75-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Amino-2-(3-nitrophenyl)propanoic acid
• CAS: 1263282-75-2
• 化学式: C9H10N2O4
• 分子量: 210.19
• InChiKey: VODQZOBRLBSVGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Pharmaceutical compositions of dimethyl fumarate
  申请人：SUN PHARMACEUTICAL INDUSTRIES LIMITED

  公开号：US10085961B2

  公开（公告）日：2018-10-02

  The present invention relates to pharmaceutical compositions comprising dimethyl fumarate and a pharmaceutically acceptable agent which inhibits the enzyme catalyzed degradation of dimethyl fumarate.

  本发明涉及由富马酸二甲酯和一种抑制富马酸二甲酯在酶催化下降解的药学上可接受的制剂组成的药物组合物。
• Methods and systems for analysis of chromatin
  申请人：10X Genomics, Inc.

  公开号：US10725027B2

  公开（公告）日：2020-07-28

  The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins) and chromatin (e.g., accessible chromatin).

  本公开提供了用于单细胞多核苷酸处理和分析表征的组合物、方法、系统和设备。这种多核苷酸处理可用于多种应用。本文公开的组合物、方法、系统和装置一般描述了条形码寡核苷酸，可与凝胶珠等珠子结合，用于表征一种或多种分析物，包括蛋白质（如细胞表面或细胞内蛋白质）和染色质（如可触及染色质）等。
• Methods and systems for analysis of major histocompatability complex
  申请人：10X Genomics, Inc.

  公开号：US10816543B2

  公开（公告）日：2020-10-27

  The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including characterization of major histocompatibility complex (MHC) molecules. The compositions, methods, systems, and devices disclosed herein generally describe peptides and barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing MHC molecules from one or more cells.

  本公开提供了从一个或多个细胞中进行多核苷酸处理和分析表征的组合物、方法、系统和装置。这种多核苷酸处理可用于多种应用，包括主要组织相容性复合体（MHC）分子的表征。本文公开的组合物、方法、系统和装置一般描述了肽和条形码寡核苷酸，它们可与凝胶珠等珠子结合，用于表征来自一个或多个细胞的 MHC 分子。
• Methods and systems for characterizing multiple analytes from individual cells or cell populations
  申请人：10X Genomics, Inc.

  公开号：US10928386B2

  公开（公告）日：2021-02-23

  The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, epigenetic information (e.g., accessible chromatin, DNA methylation), and RNA molecules (e.g., mRNA or CRISPR guide RNAs). In some cases, the disclosed methods comprise analysis of analytes from a cell using a cell bead.

  本公开提供了用于单细胞多核苷酸处理和分析表征的组合物、方法、系统和设备。这种多核苷酸处理可用于多种应用。本文公开的组合物、方法、系统和装置一般描述了条形码寡核苷酸，它们可与凝胶珠等珠子结合，用于表征一种或多种分析物，包括蛋白质（如细胞表面或细胞内蛋白质）、基因组 DNA、表观遗传信息（如可触及的染色质、DNA 甲基化）和 RNA 分子（如 mRNA 或 CRISPR 引导 RNA）。在某些情况下，所公开的方法包括使用细胞珠分析细胞中的分析物。
• Methods and systems for antigen screening
  申请人：10X Genomics, Inc.

  公开号：US11002731B2

  公开（公告）日：2021-05-11

  The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and antigen screening. Polynucleotide processing may be useful for a variety of applications. Antigen screening may comprise the use of one or more engineered cells. Engineered cells may be useful for characterizing one or more analytes including, for example, a polypeptide antigen.

  本公开提供了用于多核苷酸处理和抗原筛选的组合物、方法、系统和装置。多核苷酸处理可用于多种应用。抗原筛选可包括使用一种或多种工程细胞。工程细胞可用于表征一种或多种分析物，包括多肽抗原等。