5-Methyl-L-lysine | 61475-85-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Methyl-L-lysine
• 英文别名: (2S)-2,6-diamino-5-methylhexanoic acid
• CAS: 61475-85-2
• 化学式: C₇H₁₆N₂O₂
• 分子量: 160.21
• InChiKey: BSHGVWRQILWEKK-GDVGLLTNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] THERAPEUTIC COMPOUNDS AND METHODS<br/>[FR] COMPOSÉS ET PROCÉDÉS THÉRAPEUTIQUES
  申请人：UNIV TASMANIA

  公开号：WO2018191789A1

  公开（公告）日：2018-10-25

  The invention relates to compounds of Formula (I) and methods for their preparation. Also described are pharmaceutical compositions comprising a compound of Formula (I) and their use in the treatment or prevention of conditions associated with mitochondrial dysfunction. Formula (I)

  该发明涉及式（I）的化合物及其制备方法。还描述了包含式（I）化合物的药物组合物，以及它们在治疗或预防与线粒体功能障碍有关的疾病中的用途。Formula (I)
• A microorganism in which the fadR gene is knocked out and a process for producing L-threonine using the microorganism
  申请人：CJ Corp

  公开号：EP1408123A1

  公开（公告）日：2004-04-14

  The present invention relates to an L-threonine-producing microorganism in which the fadR gene of the microorganism has been knocked out, and a method for producing L-threonine using said mutated microorganism. The mutated microorganism of the present invention increases the production of L-threonine.

  本发明涉及一种生产 L-苏氨酸的微生物，其中该微生物的 fadR 基因已被敲除，本发明还涉及一种使用所述变异微生物生产 L-苏氨酸的方法。本发明的变异微生物提高了 L-苏氨酸的产量。
• Microorganism producing L-threonine having inactivated galR gene, method of producing the same and method of producing L-threonine using the microorganism
  申请人：CJ Corporation

  公开号：EP1561811A1

  公开（公告）日：2005-08-10

  Provided are a microorganism capable of producing L-threonine and having an inactivated galR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The microorganism can be used to produce L-threonine in high yield.

  本发明提供了一种能够生产 L-苏氨酸且具有失活 galR 基因的微生物、生产该微生物的方法以及使用该微生物生产 L-苏氨酸的方法。该微生物可用于高产生产 L-苏氨酸。
• Microorganism producing L-threonine having inactivated tyR gene, method of producing the same and method of producing L-threonine using the microorganism
  申请人：CJ Corporation

  公开号：EP1591520A2

  公开（公告）日：2005-11-02

  Provided are a microorganism capable of producing L-threonine and having an inactivated tyrR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The microorganism can be used to produce L-threonine in high yield.

  本发明提供了一种能够生产 L-苏氨酸且具有失活的 tyrR 基因的微生物、生产该微生物的方法以及使用该微生物生产 L-苏氨酸的方法。该微生物可用于高产生产 L-苏氨酸。
• L-THREONINE PRODUCING ESCHERICHIA COLI AND PROCESS FOR PRODUCING L-THREONINE USING SAME
  申请人：CJ CheilJedang Corporation

  公开号：EP2233570A1

  公开（公告）日：2010-09-29

  An L-threonine-producing Escherichia coli in which a promoter of a phosphoenolpyruvate carboxylase (ppc) gene on the chromosome is substituted with a promoter of a cysteine synthase (cysk) gene and a method of producing L-threonine by using the same are disclosed. The recombinant Escherichia coli may produce L-threonine in a high yield, and thus may be widely used in medical, pharmaceutical, and feed industries, particularly for an animal feed.

  本发明公开了一种将染色体上磷酸烯醇丙酮酸羧化酶（ppc）基因的启动子替换为半胱氨酸合成酶（cysk）基因的启动子的生产 L-苏氨酸的大肠杆菌，以及利用这种大肠杆菌生产 L-苏氨酸的方法。重组大肠杆菌可高产 L-苏氨酸，因此可广泛用于医疗、制药和饲料行业，特别是动物饲料。