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6-o-Butyrylglucose | 112018-24-3

中文名称
——
中文别名
——
英文名称
6-o-Butyrylglucose
英文别名
[(2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl] butanoate
6-o-Butyrylglucose化学式
CAS
112018-24-3
化学式
C10H18O7
mdl
——
分子量
250.25
InChiKey
JYZAAGVWAHRRRB-MVHNUAHISA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    -2
  • 重原子数:
    17
  • 可旋转键数:
    9
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.8
  • 拓扑面积:
    124
  • 氢给体数:
    4
  • 氢受体数:
    7

文献信息

  • Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
    申请人:Synlogic Operating Company, Inc.
    公开号:US10273489B2
    公开(公告)日:2019-04-30
    Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
    本研究公开了基因工程细菌、其药物组合物以及治疗或预防自身免疫性疾病、抑制肠道炎症机制和/或增强肠道粘膜屏障功能的方法。
  • Bacteria engineered to treat diseases associated with hyperammonemia
    申请人:Synlogic Operating Company, Inc.
    公开号:US11060073B2
    公开(公告)日:2021-07-13
    Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.
    本研究公开了基因工程细菌、其药物组合物以及调节和治疗与高血症相关疾病的方法。
  • Methods for manufacturing polysaccharide derivatives
    申请人:——
    公开号:US20040137582A1
    公开(公告)日:2004-07-15
    The invention is based upon the discovery that insoluble, polysaccharides, such as inulin and dextran, can be enzymatically modified in an organic solvent. Thus, the invention relates to methods for making a high molecular weight polyhydroxy polymer, such as a polysaccharide, inulin or dextran derivative, comprising reacting an acyl donor and the polymer, such as inulin or dextran, to form an acyl ester of the polymer, such as inulin dextran, in a reaction medium comprising an organic solvent in the presence of a hydrolytic enzyme; methods for making a polymer, such as a polysaccharide, an inulin or dextran polymer, comprising reacting a polymerizable acyl donor and polyhydroxyl polymer in a reaction medium comprising an organic solvent in the presence of a hydrolytic enzyme thereby making an polymeric monomer, such as an inulin monomer, and polymerizing, preferably dimerizing, the monomer, thereby making a novel polymer, such as an inulin polymer. The invention further relates to novel products as can be produced by the processes described herein, pharmaceutical compositions containing them and the use of the novel polymers described herein in methods for the manufacture of a pharmaceutical composition or medicament. Further, the invention relates to a method of delivering an active agent to a patient comprising administering to the patient a pharmaceutical composition described herein.
    本发明的基础是发现菊粉葡聚糖等不溶性多糖可以在有机溶剂中进行酶改性。因此,本发明涉及制造高分子量多羟基聚合物(如多糖菊粉葡聚糖生物)的方法,包括在解酶存在下,在包括有机溶剂的反应介质中,使酰基供体与聚合物(如菊粉葡聚糖)反应,形成聚合物(如菊粉葡聚糖)的酰基酯;制造聚合物,如多糖菊粉葡聚糖聚合物的方法,包括在解酶存在下,在包含有机溶剂的反应介质中,使可聚合酰基供体和多羟基聚合物反应,从而制得聚合物单体,如菊粉单体,并使单体聚合,最好是二聚,从而制得新型聚合物,如菊粉聚合物。本发明进一步涉及可通过本文所述工艺生产的新型产品、含有这些产品的药物组合物以及本文所述新型聚合物在药物组合物或药物制造方法中的使用。此外,本发明还涉及一种向患者施用活性剂的方法,包括向患者施用本文所述的药物组合物。
  • ENZYMATIC REVERSE HYDROLYSIS OF HYDROPHILIC SUBSTRATES - PREPARATION OF AMPHIPHILIC COMPOUNDS
    申请人:SCHNEIDER, Manfred P.
    公开号:EP0571421A1
    公开(公告)日:1993-12-01
  • CARBOXYALKYL CELLULOSE ESTERS FOR SUSTAINED DELIVERY OF PHARMACEUTICALLY ACTIVE SUBSTANCES
    申请人:EASTMAN CHEMICAL COMPANY
    公开号:EP1942869A2
    公开(公告)日:2008-07-16
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